NFKBIA/IkB alpha Antibody (B-3): sc-373893
- NFKBIA/IkB alpha Antibody (B-3) is a mouse monoclonal IgA κ, cited in 21 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 2-27 within the N-terminus of IκB-α of human origin
- recommended for detection of IκB-α of human origin by WB, IP, IF and ELISA
- See NFKBIA/IkB alpha (H-4): sc-1643 for NFKBIA/IkB alpha antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for NFKBIA/IkB alpha Antibody (B-3). This work is in progress.
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IκB-α Antibody (B-3) is a mouse monoclonal IgA antibody that detects IκB-α in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IκB-α plays a crucial role in the regulation of the NF-κB signaling pathway, which is vital for controlling immune responses, cell proliferation, and survival. By sequestering NF-κB dimers in the cytoplasm, IκB-α prevents their translocation to the nucleus, thereby inhibiting the expression of target genes involved in inflammation and immune responses. The importance of IκB-α′s function is underscored by involvement in various diseases, including cancer and autoimmune disorders, where dysregulation of NF-κB activity can lead to pathological conditions. Additionally, IκB-α undergoes post-translational modifications, such as phosphorylation, which can influence stability and interaction with NF-κB, further highlighting a critical role in cellular signaling. Anti-IκB-α antibody (B-3) is an essential tool for researchers studying the NF-κB pathway and its implications in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
NFKBIA/IkB alpha Antibody (B-3) References:
- IkappaB-alpha enhances transactivation by the HOXB7 homeodomain-containing protein. | Chariot, A., et al. 1999. J Biol Chem. 274: 5318-25. PMID: 10026139
- NF-kappaB activation and IkappaB alpha dynamism involved in iNOS and chemokine induction in astroglial cells. | Nomura, Y. 2001. Life Sci. 68: 1695-701. PMID: 11270616
- Consequences of IkappaB alpha hydroxylation by the factor inhibiting HIF (FIH). | Devries, IL., et al. 2010. FEBS Lett. 584: 4725-30. PMID: 21056038
- Sinensetin attenuates LPS-induced inflammation by regulating the protein level of IκB-α. | Shin, HS., et al. 2012. Biosci Biotechnol Biochem. 76: 847-9. PMID: 22484952
- Heat shock-mediated regulation of IκB-α at the post-transcriptional level by HuR. | Liu, Y. and Yu, W. 2014. Mol Med Rep. 9: 553-9. PMID: 24271119
- Expression of plasma nuclear factor-kappa B cells (NF-κB) and Inhibitory subunit kappa B alpha (IκB-α) in HIV-associated pre-eclampsia. | Zozo, B., et al. 2021. Hypertens Pregnancy. 40: 15-20. PMID: 33397161
- Corrigendum to 'The protective effect of 5-O-methylvisammioside on LPS-induced depression in mice by inhibiting the over activation of BV-2 microglia through Nf-κB/IκB-α pathway' [Phytomedicine 79 (2020) 153348]. | Sun, X., et al. 2021. Phytomedicine. 85: 153506. PMID: 33736908
- Diagnosis of IRAK-4-deficiency by flow cytometric measurement of IκB-α degradation. | Frans, G., et al. 2024. Clin Chem Lab Med. 62: e102-e105. PMID: 37929815
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NFKBIA/IkB alpha Antibody (B-3) | sc-373893 | 200 µg/ml | $322.00 | |||
NFKBIA/IkB alpha (B-3) Neutralizing Peptide | sc-373893 P | 100 µg/0.5 ml | $69.00 |