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IGF-1 Receptor/IGF1R Antibody (7G11) - Western Blotting - Image 22049
IGF-IR 抗体 (7G11): sc-81464. 293T (A) 和 HeLa (B) 全细胞裂解液中 IGF-IR 表达的 Western 印迹分析.
IGF-1 Receptor/IGF1R Antibody (7G11) - Western Blotting - Image 22049
IGF-IR 抗体 (7G11): sc-81464. 293T (A) 和 HeLa (B) 全细胞裂解液中 IGF-IR 表达的 Western 印迹分析.
IGF-IR 抗体 (7G11): sc-81464. 293T (A) 和 HeLa (B) 全细胞裂解液中 IGF-IR 表达的 Western 印迹分析.

IGF-1 Receptor/IGF1R 抗体 (7G11): sc-81464

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说明书
  • IGF-1 Receptor/IGF1R 抗体 7G11 是小鼠单克隆 IgG1, 在48篇文献中引用，提供 50 µg/0.5 ml
  • 针对IGF-IR的human起源的C-terminus的
  • 推荐用于 mouse, rat 和 human 来源的IGF-IR WB 和 IP检测
  • m-IgG Fc BP-HRP是IGF-1 Receptor/IGF1R Antibody (7G11) 适用于 WB 应用。 的首选辅助检测试剂。该试剂现与IGF-1 Receptor/IGF1R Antibody (7G11) 搭配使用（请参阅下面的订购信息）。

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関連項目

附加IGF Receptor抗体，包括IGF-IR, IGF-IR α, IGF-IR β和IGF-IIR

IGF-IR抗体（7G11）是一种小鼠单克隆IgG1抗体，可通过蛋白质印迹（WB）和免疫沉淀（IP）检测小鼠、大鼠和人类样本中的IGF-IR。抗IGF-IR抗体（7G11）以非结合形式提供，可在研究中广泛使用。胰岛素样生长因子-I受体（IGF-IR）作为受体酪氨酸激酶发挥着关键作用，影响细胞的生长、存活和分化等多种过程。IGF-IR位于细胞膜上，由胰岛素样生长因子-I（IGF-I）激活，后者触发一系列细胞内信号传导通路，对细胞对生长因子的反应至关重要。IGF-IR调节细胞增殖和抑制细胞凋亡的能力在癌症中尤为重要，因为IGF-IR信号异常会导致肿瘤生长和抗药性。人类IGF-IR基因位于15q26.3号染色体上，编码一种前体蛋白，该蛋白被切割成α和β亚基，对功能活性至关重要。了解IGF-IR的结构和功能对于开发肿瘤和其他生长因子信号失调疾病的靶向疗法至关重要。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

IGF-1 Receptor/IGF1R 抗体 (7G11) 参考文献:

  1. Shc和胰岛素样生长因子1受体在介导雌激素受体α向质膜转位中的作用。  |  Song, RX., et al. 2004. Proc Natl Acad Sci U S A. 101: 2076-81. PMID: 14764897
  2. 将抑制胰岛素样生长因子受体-1 酪氨酸激酶活性作为多发性骨髓瘤, 其他血液系统恶性肿瘤和实体瘤的治疗策略。  |  Mitsiades, CS., et al. 2004. Cancer Cell. 5: 221-30. PMID: 15050914
  3. I 型胰岛素样生长因子受体 mRNA 的反义寡核苷酸对体内乳腺癌生长的抑制涉及 ErbBs, PI-3K/Akt 和 p42/p44 MAPK 信号通路的失活，但不涉及对孕酮受体活性的调节。  |  Salatino, M., et al. 2004. Oncogene. 23: 5161-74. PMID: 15122317
  4. IL-1beta 会损害胰岛素样生长因子 i 诱导的分化以及胰岛素样生长因子 i 受体在成肌细胞中的下游激活信号。  |  Broussard, SR., et al. 2004. J Immunol. 172: 7713-20. PMID: 15187154
  5. 胰岛素受体底物-1/SHP-2相互作用是血管平滑肌细胞中胰岛素样生长因子-I 信号转导的表型依赖性开关机制。  |  Hayashi, K., et al. 2004. J Biol Chem. 279: 40807-18. PMID: 15272025
  6. 原发性乳腺癌中胰岛素样生长因子 1 受体的表达：免疫组化分析。  |  Shimizu, C., et al. 2004. Hum Pathol. 35: 1537-42. PMID: 15619214
  7. 胰岛素样生长因子受体-1（IGF-IR）作为前列腺癌治疗的目标。  |  Wu, J. and Yu, E. 2014. Cancer Metastasis Rev. 33: 607-17. PMID: 24414227
  8. 胰岛素样生长因子-I受体与甲状腺相关性眼病。  |  Smith, TJ. and Janssen, JAMJL. 2019. Endocr Rev. 40: 236-267. PMID: 30215690
  9. 胰岛素样生长因子I受体：肝细胞癌基因治疗的新靶点。  |  Wang, L., et al. 2019. Mini Rev Med Chem. 19: 272-280. PMID: 30360707
  10. 胰岛素和 IGF-I 受体的激活机制和信号转导特异性。受体二聚体交联, 钟形曲线以及持续信号转导与瞬时信号转导。  |  De Meyts, P., et al. 1995. Ann N Y Acad Sci. 766: 388-401. PMID: 7486684
  11. 胰岛素/IGF-1 受体跨膜信号的分子缺陷。  |  Frattali, AL. and Pessin, JE. 1993. Ann N Y Acad Sci. 687: 77-89. PMID: 8323192
  12. 通过胰岛素受体底物 1 发出胰岛素和 IGF-I 信号。  |  Keller, SR., et al. 1993. Mol Reprod Dev. 35: 346-51; discussion 351-2. PMID: 8398112

订购信息

产品名称产品编号规格价格数量收藏夹

IGF-1 Receptor/IGF1R 抗体 (7G11)

sc-81464
50 µg/0.5 ml
$316.00

IGF-1 Receptor/IGF1R (7G11): m-IgG Fc BP-HRP 套装

sc-539614
50 µg Ab; 10 µg BP
$354.00

I need to use the antibody that will not block the active site of the receptor. Will Your product suit my needs?

Asked by: hananoca
Thank you for your question. Anti-IGF-1 Receptor/IGF1R Antibody (7G11): sc-81464 is only recommended for detection of IGF-IR of mouse, rat and human origin by WB and IP. We have not tested the antibody's blocking properties and cannot say whether it would be suitable for your planned experiment.
Answered by: Tech Support Europe
Date published: 2021-11-04

I need to use an antibody to detect the protein in samples of avian origin. Do you know if this mouse monoclonal antibody will work?

Asked by: jerojero
Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity.
Answered by: Technical Support 15
Date published: 2017-01-25
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Rated 4 out of 5 by from Good antibody1:100 diluted for wb of rat heart protein,the band is special ,but not quite strong
Date published: 2020-02-02
Rated 4 out of 5 by from Anticuerpo frente al receptor de IGF-IExcelente anticuerpo para Western blot, con buena definición
Date published: 2018-03-23
Rated 5 out of 5 by from Excellent for WBThe 7G11 clone is a well established monoclonal choice for WB applications, as indicated through the more than dozen featured product citations!
Date published: 2017-01-10
Rated 4 out of 5 by from Worked well in coimmunoprecipitation assaysWorked well in coimmunoprecipitation assays.
Date published: 2016-07-22
Rated 5 out of 5 by from It works well for WB and IP in differentIt works well for WB and IP in different human cell lines.
Date published: 2015-10-12
Rated 5 out of 5 by from Published data for WB in human LNCaP and PC3 cellsPublished data for WB in human LNCaP and PC3 cells. -SCBT Publication Review
Date published: 2015-04-26
Rated 4 out of 5 by from Published data for WB in human cardiocytesPublished data for WB in human cardiocytes. -SCBT Publication Review
Date published: 2015-01-22
Rated 5 out of 5 by from Published data for WB in SkBr3 and Ishikawa cellsPublished data for WB in SkBr3 and Ishikawa cells. -SCBT Publication Review
Date published: 2015-01-10
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IGF-1 Receptor/IGF1R 抗体 (7G11) is rated 4.4 out of 5 by 9.
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