Date published: 2025-9-5
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hnRNP I Antibody (SH54) - Western Blotting - Image 359640
hnRNP I 抗体 (SH54): sc-56701. HeLa (A), Jurkat (B), A549 (C) 和 CCRF-CEM (D) 全细胞裂解液中 hnRNP I 表达的 Western 印迹分析. 所用检测试剂: m-IgGκ BP-HRP: sc-516102.
hnRNP I 抗体 (SH54): sc-56701. HeLa (A), Jurkat (B), A549 (C) 和 CCRF-CEM (D) 全细胞裂解液中 hnRNP I 表达的 Western 印迹分析. 所用检测试剂: m-IgGκ BP-HRP: sc-516102.

hnRNP I 抗体 (SH54): sc-56701

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说明书
  • hnRNP I 抗体 SH54 是小鼠单克隆 IgG1 κ，hnRNP I抗体, 在16篇文献中引用，规格为200 µg/ml
  • 针对源自human的HeLa细胞核提取物
  • hnRNP I 抗体 (SH54) 推荐用于WB, IP, IF 和 IHC(P)，检测human 来源的 hnRNP I
  • 抗hnRNP I抗体（SH54）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取hnRNP I (SH54): sc-56701的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP, m-IgG1 BP-HRP 和 m-IgGκ BP-HRP 是 hnRNP I 抗体 (SH54) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与hnRNP I 抗体 (SH54) 组合成套装提供。 (请参阅下面的订购信息)。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

此外 hnRNP 抗体 包括 hnRNP A, hnRNP A1, hnRNP A2, hnRNP B, hnRNP B1, hnRNP C1, hnRNP C2, hnRNP E1, hnRNP E2和hnRNP F

hnRNP I 抗体（SH54）是一种小鼠单克隆 IgG1 kappa 轻链抗体，可通过免疫印迹（WB）、免疫沉淀（IP）、免疫荧光（IF）和免疫组织化学方法检测人源 hnRNP I 蛋白。抗 hnRNP I 抗体 (SH54) 有非共轭型和多种共轭型，包括琼脂糖、辣根过氧化物酶 (HRP)、藻红蛋白 (PE)、异硫氰酸荧光素 (FITC) 和多种 Alexa Fluor® 共轭物。异质性核核糖核蛋白 I（hnRNP I）又称多嘧啶束结合蛋白（PTB），在调节前 mRNA 的替代剪接中起着至关重要的作用，而替代剪接对产生蛋白质多样性和调节基因表达至关重要。hnRNP I 主要定位于核质中，与内含子 3' 端结合会影响正常细胞过程中的剪接机制和某些病毒（如丙型肝炎病毒（HCV））的翻译。hnRNP I 基因位于染色体 19p13.3，它与其他 hnRNP 蛋白（如 hnRNP L）的相互作用强调了剪接体组成的重要性，而剪接体对 mRNA 的处理至关重要。hnRNP I 在细胞核和细胞质之间穿梭的能力进一步突出了它在 mRNA 转运和翻译中的重要性，使这种蛋白成为细胞功能和病毒致病机制中的关键角色。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

hnRNP I 抗体 (SH54) 参考文献:

  1. 核前 mRNA 区隔：将释放的转录本运送到剪接因子库。  |  Melcák, I., et al. 2000. Mol Biol Cell. 11: 497-510. PMID: 10679009
  2. 在细胞核和细胞质之间穿梭的 hnRNPs 之间的蛋白质相互作用。  |  Kim, JH., et al. 2000. J Mol Biol. 298: 395-405. PMID: 10772858
  3. 编码异质核核糖核蛋白 I 型（hnRNP I）的人类基因的组织和 hnRNP I 相关假基因的特征。  |  Romanelli, MG., et al. 2000. Gene. 255: 267-72. PMID: 11024286
  4. hnRNP I-vRNA的结合调节辛迪巴斯病毒结构蛋白的表达，从而提高病毒颗粒的感染性。  |  Westcott, CE., et al. 2022. Viruses. 14: PMID: 35891402
  5. 增加膳食营养水平可调节结肠免疫适应并减轻上皮异质核糖核蛋白 I（Hnrnp I）基因敲除小鼠的炎症。  |  Xu, GB., et al. 2023. J Nutr Biochem. 119: 109406. PMID: 37394079
  6. 单细胞 RNA 测序（scRNA-seq）确定 L1CAM 是 Hnrnp I 基因敲除小鼠结肠上皮簇状细胞和固有淋巴细胞之间的关键介质。  |  Xu, GB., et al. 2023. Biomedicines. 11: PMID: 37893107
  7. hnRNP A1 蛋白的核定位结构域。  |  Siomi, H. and Dreyfuss, G. 1995. J Cell Biol. 129: 551-60. PMID: 7730395
  8. 新型人类 RNA 结合蛋白的鉴定和特性分析。  |  Badolato, J., et al. 1995. Gene. 166: 323-7. PMID: 8543184
  9. 多个 RRM 有助于提高 RNA 结合的特异性和多嘧啶束结合蛋白的亲和力。  |  Pérez, I., et al. 1997. Biochemistry. 36: 11881-90. PMID: 9305981
  10. 多嘧啶束结合蛋白与 HnRNP L 相互作用  |  Hahm, B., et al. 1998. FEBS Lett. 425: 401-6. PMID: 9563502
  11. 异质核糖核蛋白 L 与丙型肝炎病毒内部核糖体入口位点的 3' 边界相互作用。  |  Hahm, B., et al. 1998. J Virol. 72: 8782-8. PMID: 9765422
  12. 多嘧啶束结合蛋白与小鼠肝炎病毒的领导 RNA 结合，是病毒转录的调节因子。  |  Li, HP., et al. 1999. J Virol. 73: 772-7. PMID: 9847386

订购信息

产品名称产品编号规格价格数量收藏夹

hnRNP I 抗体 (SH54)

sc-56701
200 µg/ml
$316.00

hnRNP I (SH54): m-IgG Fc BP-HRP 套装

sc-528618
200 µg Ab; 10 µg BP
$354.00

hnRNP I (SH54): m-IgGκ BP-HRP 套装

sc-521041
200 µg Ab, 40 µg BP
$354.00

hnRNP I (SH54): m-IgG1 BP-HRP 套装

sc-543031
200 µg Ab; 20 µg BP
$354.00

hnRNP I 抗体 (SH54) AC

sc-56701 AC
500 µg/ml, 25% agarose
$416.00

hnRNP I 抗体 (SH54) HRP

sc-56701 HRP
200 µg/ml
$316.00

hnRNP I 抗体 (SH54) FITC

sc-56701 FITC
200 µg/ml
$330.00

hnRNP I 抗体 (SH54) PE

sc-56701 PE
200 µg/ml
$343.00

hnRNP I 抗体 (SH54) Alexa Fluor® 488

sc-56701 AF488
200 µg/ml
$357.00

hnRNP I 抗体 (SH54) Alexa Fluor® 546

sc-56701 AF546
200 µg/ml
$357.00

hnRNP I 抗体 (SH54) Alexa Fluor® 594

sc-56701 AF594
200 µg/ml
$357.00

hnRNP I 抗体 (SH54) Alexa Fluor® 647

sc-56701 AF647
200 µg/ml
$357.00

hnRNP I 抗体 (SH54) Alexa Fluor® 680

sc-56701 AF680
200 µg/ml
$357.00

hnRNP I 抗体 (SH54) Alexa Fluor® 790

sc-56701 AF790
200 µg/ml
$357.00

I need to use an antibody to detect the protein in samples of equine origin. Do you know if this mouse monoclonal antibody will work?

Asked by: jerojero
Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity.
Answered by: Technical Support 3
Date published: 2017-02-14
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Rated 4 out of 5 by from Muito bomPedi uma amostra e tive resultados muito bons em WB 1:500. Banda especifica e sem background.
Date published: 2018-05-08
Rated 5 out of 5 by from Good for WB, IHC and IFAntibody specificity is very good. Strong and clear band in WB at 1:200, 769P and ACHN cells. Good staining in IHC at 1:200, renal cancer tissue .Good staining in IF at 1:100, UM-UC-3 and 5637 cells.
Date published: 2017-09-11
Rated 5 out of 5 by from Suitable for Western BlotWorks very well in Western Blot done with recombinant protein.
Date published: 2017-09-07
Rated 5 out of 5 by from Great for WBThis is a reliable antibody that consistently provides data at the correct weight while giving clear and specific signal. This product has been featured in several published papers.
Date published: 2017-02-08
Rated 5 out of 5 by from Nice publishable WB data on human MCFNice publishable WB data on human MCF-7 cells. -SCBT Publication Review
Date published: 2015-04-29
Rated 4 out of 5 by from Performs well in WesternPerforms well in Western, good signal with human HEK-293 FLP-In cells. -SCBT Publication Review
Date published: 2015-03-28
Rated 5 out of 5 by from This antibody works in many different cellThis antibody works in many different cell lines such as MEG-01, HeLa and A549 nuclear extracts and SHP-77 and HeLa whole cell lysates. -SCBT QC
Date published: 2015-02-05
Rated 5 out of 5 by from WB: Worked well in human colorectal samplesWB: Worked well in human colorectal samples. -SCBT Publication Review
Date published: 2015-02-04
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hnRNP I 抗体 (SH54) is rated 4.8 out of 5 by 9.
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