Date published: 2025-10-10

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HIV-1 Integrase 抗体 (IN-2): sc-69721

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说明书
  • HIV-1 Integrase 抗体 IN-2 是小鼠单克隆 IgG1 κ,HIV-1 Integrase抗体, 在11篇文献中引用,规格为200 µg/ml
  • 针对HIV-1 Integrase
  • HIV-1 Integrase 抗体 (IN-2) 推荐用于WB, IP 和 IF,检测HIV-1 来源的 Pol Integrase
  • 抗HIV-1 Integrase抗体(IN-2)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • m-IgG Fc BP-HRP1 BP-HRP">m-IgG1 BP-HRP是HIV-1 Integrase Antibody (IN-2) for WB applications. 的首选辅助检测试剂,这些试剂现与HIV-1 Integrase Antibody (IN-2) 打包提供(请参阅下面的订购信息)。

快捷链接

関連項目

HIV-1整合酶抗体(IN-2)是一种小鼠单克隆IgG1 kappa轻链抗体,可通过蛋白质印迹(WB)、免疫沉淀(IP)和免疫荧光(IF)检测HIV-1来源的HIV-1整合酶蛋白。抗HIV-1整合酶抗体(IN-2)有非结合型和多种结合型,包括琼脂糖、辣根过氧化物酶(HRP)、藻红蛋白(PE)、异硫氰酸荧光素(FITC)和多种Alexa Fluor®结合物。HIV-1整合酶在病毒生命周期中起着至关重要的作用,它促进病毒DNA整合到宿主细胞的基因组中,这一过程对于病毒复制至关重要。通过整合到宿主遗传物质中,病毒可以逃避宿主的免疫反应。HIV-1整合酶通过精确的DNA切割和连接反应发挥作用,这对于病毒DNA准确插入宿主基因组至关重要。HIV-1整合酶(IN-2)抗体识别一种蛋白质,其结构完整性由C端结构域维持,形成类似于Src同源3(SH3)结构域的同源二聚体,而N端结构域包含锌结合和蛋白质稳定性所必需的保守HHCC结构域。这种独特的结构配置强调了HIV-1整合酶在病毒复制中的重要性,并为HIV治疗策略提供了潜在的治疗靶点。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

HIV-1 Integrase 抗体 (IN-2) 参考文献:

  1. HIV-1 感染需要功能性整合酶 NLS。  |  Bouyac-Bertoia, M., et al. 2001. Mol Cell. 7: 1025-35. PMID: 11389849
  2. HIV-1 整合酶的 DNA 结合域具有类似 SH3 的折叠。  |  Eijkelenboom, AP., et al. 1995. Nat Struct Biol. 2: 807-10. PMID: 7552753
  3. HIV-1 整合酶催化结构域的晶体结构:与其他多核苷酸转移酶的相似性。  |  Dyda, F., et al. 1994. Science. 266: 1981-6. PMID: 7801124
  4. 酵母转录因子 SNF5 的人类同源物对 HIV-1 整合酶的结合与刺激。  |  Kalpana, GV., et al. 1994. Science. 266: 2002-6. PMID: 7801128
  5. 鉴定 HIV-1 整合酶的离散功能域及其在活性多聚体复合物中的组织结构。  |  Engelman, A., et al. 1993. EMBO J. 12: 3269-75. PMID: 8344264
  6. 锌能折叠 HIV-1 整合酶的 N 端结构域,促进多聚化,并增强催化活性。  |  Zheng, R., et al. 1996. Proc Natl Acad Sci U S A. 93: 13659-64. PMID: 8942990
  7. HIV-1 整合酶 N 端锌结合域的溶液结构。  |  Cai, M., et al. 1997. Nat Struct Biol. 4: 567-77. PMID: 9228950
  8. HIV-1 通过导入素/核糖体途径识别整合酶感染非分裂细胞。  |  Gallay, P., et al. 1997. Proc Natl Acad Sci U S A. 94: 9825-30. PMID: 9275210
  9. HIV-1 整合酶核心结构域的三个新结构:结合镁的活性位点。  |  Goldgur, Y., et al. 1998. Proc Natl Acad Sci U S A. 95: 9150-4. PMID: 9689049

订购信息

产品名称产品编号规格价格数量收藏夹

HIV-1 Integrase 抗体 (IN-2)

sc-69721
200 µg/ml
$316.00

HIV-1 Integrase (IN-2): m-IgG Fc BP-HRP 套装

sc-526982
200 µg Ab; 10 µg BP
$354.00

HIV-1 Integrase (IN-2): m-IgG1 BP-HRP 套装

sc-532355
200 µg Ab; 20 µg BP
$354.00

HIV-1 Integrase 抗体 (IN-2) AC

sc-69721 AC
500 µg/ml, 25% agarose
$416.00

HIV-1 Integrase 抗体 (IN-2) HRP

sc-69721 HRP
200 µg/ml
$316.00

HIV-1 Integrase 抗体 (IN-2) FITC

sc-69721 FITC
200 µg/ml
$330.00

HIV-1 Integrase 抗体 (IN-2) PE

sc-69721 PE
200 µg/ml
$343.00

HIV-1 Integrase 抗体 (IN-2) Alexa Fluor® 488

sc-69721 AF488
200 µg/ml
$357.00

HIV-1 Integrase 抗体 (IN-2) Alexa Fluor® 546

sc-69721 AF546
200 µg/ml
$357.00

HIV-1 Integrase 抗体 (IN-2) Alexa Fluor® 594

sc-69721 AF594
200 µg/ml
$357.00

HIV-1 Integrase 抗体 (IN-2) Alexa Fluor® 647

sc-69721 AF647
200 µg/ml
$357.00

HIV-1 Integrase 抗体 (IN-2) Alexa Fluor® 680

sc-69721 AF680
200 µg/ml
$357.00

HIV-1 Integrase 抗体 (IN-2) Alexa Fluor® 790

sc-69721 AF790
200 µg/ml
$357.00

What is the amino acid sequence used to produce this antibody? What region of the Integrase constitute its target? Thanks

Asked by: Ramirez Q
Thank you for your question. Anti-HIV-1 Integrase Antibody (IN-2): sc-69721 was raised against HIV-1 Integrase. No epitope mapping has been performed for this antibody as of yet, so the exact amino acid range it targets or the targeted region of the protein is not known.
Answered by: Tech Support Europe
Date published: 2022-05-30

What is the recommended secondary for HIV-1 Integrase (IN-2): sc-69721 monoclonal antibody?

Asked by: AbPolly
Thank you for your question. We recommend using one our exclusive Mouse IgG Binding Proteins as a secondary detection reagent. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
Answered by: Technical Support
Date published: 2017-03-07
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Rated 5 out of 5 by from Great Service - Excellent product!The product worked perfectly for the experiment I was conducting
Date published: 2021-04-13
Rated 4 out of 5 by from Positive results in western blot analysis of HIVPositive results in western blot analysis of HIV-1 Integrase expression in semi-purified HIV-1 virions. -SCBT QC
Date published: 2014-01-09
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HIV-1 Integrase 抗体 (IN-2) is rated 4.5 out of 5 by 2.
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