Date published: 2025-9-7
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Histone Deacetylase 7 (HDAC7) Antibody (A-7) - Western Blotting - Image 359942
HDAC7 抗体 (A-7): sc-74563. Western 印迹分析 HDAC7 在 NIH: OVCAR-3 (A), HuT 78 (B), Ramos (C), Raji (D) 和 NCI-H929 (E) 全细胞裂解液中 HDAC7 表达的 Western 印迹分析.
HDAC7 抗体 (A-7): sc-74563. Western 印迹分析 HDAC7 在 NIH: OVCAR-3 (A), HuT 78 (B), Ramos (C), Raji (D) 和 NCI-H929 (E) 全细胞裂解液中 HDAC7 表达的 Western 印迹分析.

Histone Deacetylase 7 (HDAC7) 抗体 (A-7): sc-74563

4.3(7)
寫評論提問

说明书
  • Histone Deacetylase 7 (HDAC7) 抗体 A-7 是小鼠单克隆 IgG2a κ，Histone Deacetylase 7 (HDAC7)抗体, 在25篇文献中引用，规格为200 µg/ml
  • 免疫human物种的HDAC7的氨基酸163-435
  • Histone Deacetylase 7 (HDAC7) 抗体 (A-7) 推荐用于WB, IP, IF 和 ELISA，检测human 来源的 HDAC7
  • 抗Histone Deacetylase 7 (HDAC7)抗体（A-7）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 可用于凝胶迁移和ChIP的TransCruz试剂(sc-74563 X, 200 µg/0.1 ml)
  • 关于如何获取Histone Deacetylase 7 (HDAC7) (A-7): sc-74563的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP和 2a BP-HRP">m-IgG2a BP-HRP是Histone Deacetylase 7 (HDAC7) Antibody (A-7) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与Histone Deacetylase 7 (HDAC7) Antibody (A-7) 打包提供（请参阅下面的订购信息）。

快捷链接

相关产品
描述
基因信息
蛋白序列
说明书与实验方案
研究信息

関連項目

额外HDAC抗体，包括HDAC1, HDAC10, HDAC11, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8和HDAC9

HDAC7抗体（A-7）是一种IgG2a κ小鼠单克隆HDAC7抗体（也称为组蛋白去乙酰化酶7抗体），可通过WB、IP、IF和ELISA检测人源HDAC7蛋白。HDAC7抗体（A-7）既有非偶联抗HDAC7抗体形式，也有多种偶联形式的抗HDAC7抗体，包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。在完整的细胞中，DNA与组蛋白和其他核蛋白紧密结合形成染色质。人们认为染色质的重塑是转录调控的关键组成部分，而这种重塑的主要来源是由核小体组蛋白的乙酰化引起的。组蛋白氨基端尾部结构域中赖氨酸残基的乙酰化导致核小体构象发生别构变化，并增加了DNA对转录因子的可及性。相反，组蛋白的去乙酰化与转录沉默有关。已经鉴定出几种哺乳动物蛋白为核组蛋白乙酰基转移酶，包括GCN5、PCAF（p300/CBP相关因子）、p300/CBP、HAT1和TFIID亚基TAF II p250。哺乳动物HDAC7是一种组蛋白去乙酰化酶，与适配子mSin3A相互作用。HDAC7与mSin3A的相互作用表明转录因子的多个阻遏复合物的关联。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Histone Deacetylase 7 (HDAC7) 抗体 (A-7) 参考文献:

  1. 新型组蛋白去乙酰化酶的分离揭示了 I 类和 II 类去乙酰化酶可促进 SMRT 介导的抑制作用。  |  Kao, HY., et al. 2000. Genes Dev. 14: 55-66. PMID: 10640276
  2. Hdac7通过抑制Stat3活化促进肺肿瘤发生  |  Lei, Y., et al. 2017. Mol Cancer. 16: 170. PMID: 29126425
  3. HDAC7通过去泛素化酶USP10的稳定和β-catenin-FGF18通路的激活促进NSCLC的增殖和转移。  |  Guo, K., et al. 2022. J Exp Clin Cancer Res. 41: 91. PMID: 35277183
  4. HDAC7-TET2 表观遗传轴在早期 B 淋巴细胞发育过程中至关重要。  |  Azagra, A., et al. 2022. Nucleic Acids Res. 50: 8471-8490. PMID: 35904805
  5. 褪黑激素通过减轻 HDAC7/β-catenin/c-Myc 正反馈环路和抑制 USP10 维护的 HDAC7 蛋白稳定性来抑制 ESCC 肿瘤的生长。  |  Ma, ZQ., et al. 2022. Mil Med Res. 9: 54. PMID: 36163081
  6. HDAC7 是一种免疫代谢开关，可对巨噬细胞中的危险信号进行分流，使其参与抗微生物反应和炎症反应。  |  Das Gupta, K., et al. 2023. Proc Natl Acad Sci U S A. 120: e2212813120. PMID: 36649417
  7. HDAC7/c-Myc 信号通路促进脉络膜黑色素瘤细胞的增殖和转移。  |  Zhang, Y., et al. 2023. Cell Death Dis. 14: 38. PMID: 36653340
  8. 乙酰化导致的核小体结构变化  |  Bauer, WR., et al. 1994. J Mol Biol. 236: 685-90. PMID: 8114086
  9. 组蛋白乙酰化在转录因子进入核糖体 DNA 的过程中发挥了积极作用。  |  Lee, DY., et al. 1993. Cell. 72: 73-84. PMID: 8422685
  10. 酵母的转录沉默与核小体乙酰化减少有关。  |  Braunstein, M., et al. 1993. Genes Dev. 7: 592-604. PMID: 8458576
  11. 核糖体 DNA 调节人类 Hat1 乙酰转移酶的核心-活素结合亚基。  |  Verreault, A., et al. 1998. Curr Biol. 8: 96-108. PMID: 9427644
  12. 转录激活剂将组蛋白乙酰转移酶复合物导向核糖体。  |  Utley, RT., et al. 1998. Nature. 394: 498-502. PMID: 9697775

订购信息

产品名称产品编号规格价格数量收藏夹

Histone Deacetylase 7 (HDAC7) 抗体 (A-7)

sc-74563
200 µg/ml
$316.00

Histone Deacetylase 7 (HDAC7) (A-7): m-IgG Fc BP-HRP 套装

sc-525731
200 µg Ab; 10 µg BP
$354.00

Histone Deacetylase 7 (HDAC7) (A-7): m-IgG2a BP-HRP 套装

sc-546385
200 µg Ab; 10 µg BP
$354.00

Histone Deacetylase 7 (HDAC7) 抗体 (A-7) X

sc-74563 X
200 µg/0.1 ml
$316.00

Histone Deacetylase 7 (HDAC7) 抗体 (A-7) AC

sc-74563 AC
500 µg/ml, 25% agarose
$416.00

Histone Deacetylase 7 (HDAC7) 抗体 (A-7) HRP

sc-74563 HRP
200 µg/ml
$316.00

Histone Deacetylase 7 (HDAC7) 抗体 (A-7) FITC

sc-74563 FITC
200 µg/ml
$330.00

Histone Deacetylase 7 (HDAC7) 抗体 (A-7) PE

sc-74563 PE
200 µg/ml
$343.00

Histone Deacetylase 7 (HDAC7) 抗体 (A-7) Alexa Fluor® 488

sc-74563 AF488
200 µg/ml
$357.00

Histone Deacetylase 7 (HDAC7) 抗体 (A-7) Alexa Fluor® 546

sc-74563 AF546
200 µg/ml
$357.00

Histone Deacetylase 7 (HDAC7) 抗体 (A-7) Alexa Fluor® 594

sc-74563 AF594
200 µg/ml
$357.00

Histone Deacetylase 7 (HDAC7) 抗体 (A-7) Alexa Fluor® 647

sc-74563 AF647
200 µg/ml
$357.00

Histone Deacetylase 7 (HDAC7) 抗体 (A-7) Alexa Fluor® 680

sc-74563 AF680
200 µg/ml
$357.00

Histone Deacetylase 7 (HDAC7) 抗体 (A-7) Alexa Fluor® 790

sc-74563 AF790
200 µg/ml
$357.00

Can the TransCruz reagent sc-74563 X be used in applications other than ChIP?

Asked by: AbPolly
Thank you for your question. Yes, the X form of the antibody can be used for any listed application. The dilution just needs to be changed as it is ten times as concentrated as the standard antibody.
Answered by: Technical Support 3
Date published: 2017-02-09
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Rated 3 out of 5 by from also detected another smaller size bandUsing human blood monocyte derived macrophages, we could detect a faint band at right size. 25 ug total cell lysate per lane, 1:500 1Ab dilution in milk, 2nd Ab 1:4000 CST anti-mouse, 10 min exposure. Also there is a slightly stronger band at size <25kda.
Date published: 2021-07-02
Rated 5 out of 5 by from works wellit works well for western blotting in human podocytes
Date published: 2019-11-14
Rated 5 out of 5 by from Great HDAC7 detectionThis antibody works great in WB. It will provide strong specific signals and can even be used in your staining procedures. This product has been cited several times.
Date published: 2017-01-27
Rated 5 out of 5 by from Good WBDistinct band obtained at ~110 KDa band observed on 10 ug MDA-MB-231 whole cell lysates at 1:1000 dilution.
Date published: 2016-12-12
Rated 4 out of 5 by from Good antibodyGood antibody, worked well in K-562 nuclear extracts -SCBT QC
Date published: 2015-03-23
Rated 4 out of 5 by from Worked well in transfected 293T cellsWorked well in transfected 293T cells -SCBT QC
Date published: 2015-03-12
Rated 4 out of 5 by from Strong bands in WB in Hela and MCF7 nuclearStrong bands in WB in Hela and MCF7 nuclear extracts -SCBT QC
Date published: 2013-10-12
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Histone Deacetylase 7 (HDAC7) 抗体 (A-7) is rated 4.3 out of 5 by 7.
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