Date published: 2025-9-7

021-6093-6350

SCBT Portrait Logo
Seach Input

GR/NR3C1/Glucocorticoid Receptor 抗体 (3D5): sc-56851

5.0(3)
寫評論提問

说明书
  • GR/NR3C1/Glucocorticoid Receptor 抗体 3D5 是小鼠单克隆 IgG1, 在21篇文献中引用,提供 100 µg/ml
  • 与来自Human的GR的肽段杂交
  • 推荐用于 mouse, rat 和 human 来源的GR WB, IF, IHC(P) 和 FCM检测; 不会与 TGB, BSA and KLH产生交联反应
  • 看 GR/NR3C1/Glucocorticoid Receptor (G-5): sc-393232,可查看有标记的 GR/NR3C1/Glucocorticoid Receptor 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • 关于如何获取GR/NR3C1/Glucocorticoid Receptor (3D5): sc-56851免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • 目前,我们还没有完成GR/NR3C1/Glucocorticoid Receptor 抗体 (3D5)的首选二抗检测试剂的鉴定。这项工作正在进行中。

快捷链接

関連項目

GR/NR3C1/糖皮质激素受体抗体(3D5)是一种IgG1小鼠单克隆GR抗体,可通过WB、IF、IHC(P)和FCM检测小鼠、大鼠和人源的GR。 GR/NR3C1/糖皮质激素受体抗体(3D5)可作为非偶联的抗GR抗体形式提供。糖皮质激素受体(GR)是一种普遍表达的转录因子,介导糖皮质激素的作用。最丰富的同工型是GRα。 GR诱导或抑制基因表达以响应糖皮质激素,介导细胞凋亡、细胞生长和分化等过程。 GR抑制的一类重要基因由转录因子AP-1控制。 GR也被证明是糖皮质激素诱导基因表达的限制因素。已经发现GR与HSP 90形成复合物,使非配体结合受体转录失活。更重要的是,缺乏信号传导域的突变GR保持组成型活性。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

GR/NR3C1/Glucocorticoid Receptor 抗体 (3D5) 参考文献:

  1. 糖皮质激素受体对转录调控表面的靶标特异性利用。  |  Rogatsky, I., et al. 2003. Proc Natl Acad Sci U S A. 100: 13845-50. PMID: 14617768
  2. 至少有三个启动子指导小鼠糖皮质激素受体基因的表达。  |  Strähle, U., et al. 1992. Proc Natl Acad Sci U S A. 89: 6731-5. PMID: 1495961
  3. 糖皮质激素受体转基因小鼠作为抑郁症模型。  |  Chourbaji, S. and Gass, P. 2008. Brain Res Rev. 57: 554-60. PMID: 17524489
  4. 抑郁症中的糖皮质激素受体多态性。  |  Claes, S. 2009. Ann N Y Acad Sci. 1179: 216-28. PMID: 19906242
  5. 功能性人糖皮质激素受体 cDNA 的初级结构和表达。  |  Hollenberg, SM., et al. 1985. Nature. 318: 635-41. PMID: 2867473
  6. SRSF4-GAS5-糖皮质激素受体轴调节心室肥大。  |  Larrasa-Alonso, J., et al. 2021. Circ Res. 129: 669-683. PMID: 34333993
  7. 糖皮质激素受体多态性与肾移植后的血管性骨坏死  |  Etemadi, J., et al. 2023. Iran J Kidney Dis. 1: 86-91. PMID: 37060342
  8. 抑制糖皮质激素受体,增强化疗反应。  |  Prekovic, S. and Zwart, W. 2023. J Clin Oncol. 41: 4790-4793. PMID: 37535891
  9. 握紧和折叠:伴侣和信号转导。  |  Bohen, SP., et al. 1995. Science. 268: 1303-4. PMID: 7761850
  10. 胚胎视网膜中糖皮质激素受体表达和分区的发育变化  |  Gorovits, R., et al. 1994. Proc Natl Acad Sci U S A. 91: 4786-90. PMID: 7910964
  11. 糖皮质激素受体与热休克蛋白 90 组装成功能性异质复合物所需的所有因子都预先在一个自给自足的蛋白质折叠结构--'折叠体 '中结合在一起。  |  Hutchison, KA., et al. 1994. J Biol Chem. 269: 27894-9. PMID: 7961721
  12. 糖皮质激素受体单体在抑制转录因子 AP-1 活性方面的独特调节结构域。  |  Heck, S., et al. 1994. EMBO J. 13: 4087-95. PMID: 8076604

订购信息

产品名称产品编号规格价格数量收藏夹

GR/NR3C1/Glucocorticoid Receptor 抗体 (3D5)

sc-56851
100 µg/ml
$316.00

Your product information states that this antibody is "raised against a peptide fragment of GR of human GR". Can you tell me where exactly on the GR protein the antibody recognizes (ie-N-terminus, DNA binding domain)?

Asked by: JScheimann
Thank you for your question. This antibody is raised against a peptide mapping within the N-terminal domain, not within the DNA binding domain.
Answered by: Technical Support
Date published: 2019-08-17

What is the recommended secondary reagent to be used with this mouse monoclonal primary?

Asked by: jerojero
We recommend using one our exclusive Mouse IgG Binding Proteins as a secondary detection reagent. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
Answered by: Technical Support 15
Date published: 2017-01-24
  • y_2025, m_8, d_27, h_5CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_2
  • loc_zh_CN, sid_56851, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getContent, 103ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from Excellent functionI bought this product. It's very easy to use.I recommend you to buy this product.
Date published: 2021-03-31
Rated 5 out of 5 by from Very strong antibody!Whether it's for WB or FCM, or ChIP or IF, this is a great choice for all your GR detection needs.
Date published: 2017-01-12
Rated 5 out of 5 by from Excellent indirectExcellent indirect, intracellular FCM analysis of fixed and permeabilized A-431 cells stained with GR . -SCBT QC
Date published: 2014-05-24
  • y_2025, m_8, d_27, h_5
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_3
  • loc_zh_CN, sid_56851, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getReviews, 7ms
  • REVIEWS, PRODUCT
GR/NR3C1/Glucocorticoid Receptor 抗体 (3D5) is rated 5.0 out of 5 by 3.
  • y_2025, m_8, d_27, h_5
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_3
  • loc_zh_CN, sid_56851, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getAggregateRating, 99ms
  • REVIEWS, PRODUCT