Date published: 2025-9-6
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FOXP2 Antibody (5C11A8) - Western Blotting - Image 399492
FOXP2 抗体 (5C11A8) HRP: sc-517261 HRP. 非转染: sc-117752 (A) 和人 FOXP2 转染: sc-372825 (B) 全细胞裂解液中 FOXP2 表达的直接 Western 印迹分析.
FOXP2 抗体 (5C11A8) HRP: sc-517261 HRP. 非转染: sc-117752 (A) 和人 FOXP2 转染: sc-372825 (B) 全细胞裂解液中 FOXP2 表达的直接 Western 印迹分析.

FOXP2 抗体 (5C11A8): sc-517261

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寫評論提問

说明书
  • FOXP2 抗体 5C11A8 是小鼠单克隆 IgG1 κ，FOXP2抗体, 在4篇文献中引用，规格为200 µg/ml
  • 免疫human物种的的氨基酸47-287
  • FOXP2 抗体 (5C11A8) 推荐用于WB, IP 和 ELISA，检测human 来源的 FOXP2
  • 抗FOXP2抗体（5C11A8）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取FOXP2 (5C11A8): sc-517261的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP、 1 BP-HRP">m-IgG1 BP-HRP和m-IgGκ BP-HRP是FOXP2 Antibody (5C11A8) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与FOXP2 Antibody (5C11A8) 打包提供（请参阅下面的订购信息）。

快捷链接

相关产品
描述
基因信息
说明书与实验方案
研究信息

関連項目

额外FOX抗体，包括FOXC1, FOXC2, FOXD1, FOXD3, FOXE3, FOXF2, FOXJ1, FOXJ2, FOXK1, FOXL1, FOXL2, FOXM1, FOXN1, FOXN2, FOXN4和FOXP1

FOXP2抗体（5C11A8）是一种小鼠单克隆IgG1 kappa轻链抗体，可通过蛋白质印迹（WB）、免疫沉淀（IP）和酶联免疫吸附测定（ELISA）检测人源FOXP2蛋白。抗FOXP2抗体（5C11A8）有非结合型和多种结合型，包括琼脂糖、辣根过氧化物酶（HRP）、藻红蛋白（PE）、异硫氰酸荧光素（FITC）和多种Alexa Fluor®结合物。FOXP2蛋白是一种重要的转录因子，在涉及语音和语言的神经回路发育中发挥着重要作用，因此FOXP2对于人类有效沟通至关重要。FOXP2基因的突变与语言和语音障碍有关，这凸显了FOXP2在认知发育和社会互动中的重要性。FOXP2蛋白主要位于细胞核中，FOXP2与特定的DNA序列结合，从而调节目标基因的表达，进而影响神经元的发育和功能。了解FOXP2在大脑中的作用，有助于我们深入了解语言习得和人类沟通进化的分子机制。FOXP2基因位于7q31号染色体上，FOXP2的表达在发育过程中受到严格调控，尤其是在与语言处理相关的脑区。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

FOXP2 参考文献:

  1. 人类 7q31 上的 SPCH1 区域：关键区间的基因组特征以及与言语和语言障碍相关的易位定位。  |  Lai, CS., et al. 2000. Am J Hum Genet. 67: 357-68. PMID: 10880297
  2. 免疫调节紊乱, 多内分泌病, 肠病, X 连锁综合征（IPEX）是由 FOXP3 基因突变引起的。  |  Bennett, CL., et al. 2001. Nat Genet. 27: 20-1. PMID: 11137993
  3. 一种新的叉头/翼螺旋蛋白--scurfin--的破坏导致了scurfy小鼠致命的淋巴组织增生性疾病。  |  Brunkow, ME., et al. 2001. Nat Genet. 27: 68-73. PMID: 11138001
  4. 在肺部表达并作为转录抑制因子的翼螺旋/叉头（Fox）基因新亚科的特征。  |  Shu, W., et al. 2001. J Biol Chem. 276: 27488-97. PMID: 11358962
  5. Scurfin（FOXP3）是一种转录抑制因子，可调节 T 细胞的活化。  |  Schubert, LA., et al. 2001. J Biol Chem. 276: 37672-9. PMID: 11483607
  6. FOXP1翼螺旋转录因子是染色体 3p 上的一个新的候选肿瘤抑制基因。  |  Banham, AH., et al. 2001. Cancer Res. 61: 8820-9. PMID: 11751404
  7. MAOA和FOXP2在韩国人群中的相互作用与自闭症和语言沟通有关。  |  Park, Y., et al. 2014. J Child Neurol. 29: NP207-11. PMID: 24356376
  8. FOXP2的寡聚化和DNA结合的剖析。  |  Häußermann, K., et al. 2019. Angew Chem Int Ed Engl. 58: 7662-7667. PMID: 30887622
  9. 通过上调叉头框蛋白P2（FOXP2）蛋白，下调miR-222-3p逆转了LoVo细胞对阿霉素的耐药性。  |  Wang, H., et al. 2019. Med Sci Monit. 25: 2169-2178. PMID: 30904920
  10. Foxp2 突变通过增加 GABAB/GIRK 信号传导，损害第六层皮层-丘脑细胞中的神经元增益。  |  Druart, M., et al. 2020. J Neurosci. 40: 8543-8555. PMID: 33020214
  11. β-catenin通过多个结合位点调节FOXP2的转录活性。  |  Richter, G., et al. 2021. FEBS J. 288: 3261-3284. PMID: 33284517
  12. FOXP2 过度表达上调 LAMA4 表达，从而通过调节滋养层行为减轻先兆子痫。  |  Liu, S., et al. 2024. Commun Biol. 7: 1427. PMID: 39487340

订购信息

产品名称产品编号规格价格数量收藏夹

FOXP2 抗体 (5C11A8)

sc-517261
200 µg/ml
$316.00

FOXP2 (5C11A8): m-IgG Fc BP-HRP 套装

sc-531570
200 µg Ab; 10 µg BP
$354.00

FOXP2 (5C11A8): m-IgGκ BP-HRP 套装

sc-525298
200 µg Ab, 40 µg BP
$354.00

FOXP2 (5C11A8): m-IgG1 BP-HRP 套装

sc-544630
200 µg Ab; 20 µg BP
$354.00

FOXP2 抗体 (5C11A8) AC

sc-517261 AC
500 µg/ml, 25% agarose
$416.00

FOXP2 抗体 (5C11A8) HRP

sc-517261 HRP
200 µg/ml
$316.00

FOXP2 抗体 (5C11A8) FITC

sc-517261 FITC
200 µg/ml
$330.00

FOXP2 抗体 (5C11A8) PE

sc-517261 PE
200 µg/ml
$343.00

FOXP2 抗体 (5C11A8) Alexa Fluor® 488

sc-517261 AF488
200 µg/ml
$357.00

FOXP2 抗体 (5C11A8) Alexa Fluor® 546

sc-517261 AF546
200 µg/ml
$357.00

FOXP2 抗体 (5C11A8) Alexa Fluor® 594

sc-517261 AF594
200 µg/ml
$357.00

FOXP2 抗体 (5C11A8) Alexa Fluor® 647

sc-517261 AF647
200 µg/ml
$357.00

FOXP2 抗体 (5C11A8) Alexa Fluor® 680

sc-517261 AF680
200 µg/ml
$357.00

FOXP2 抗体 (5C11A8) Alexa Fluor® 790

sc-517261 AF790
200 µg/ml
$357.00

Which secondary antibodies can be used for fluorescent labeling of this antibody?

Asked by: hl2022
Thank you for your question. FOXP2 Antibody (5C11A8): sc-517261 is a mouse monoclonal IgG1 κ antibody. It can be detected with one of our Anti-Mouse IgG Fc Binding Proteins, Anti-Mouse IgG1 Binding Proteins, or Anti-Mouse IgG Kappa Binding Proteins. You can find these products under this link: https://www.scbt.com/browse/SUPPORT-PRODUKTE-Mouse-IgG-Binding-Proteins/_/N-130b1ry?&_requestid=1269219
Answered by: Tech Support Europe
Date published: 2021-03-03

Is there a recommended protocol for IF/IHC using this FoxP2 antibody (5C11A8)? I tried in rat tissue at 1:200, with negative results. I did not use an antigen retrieval procedure.

Asked by: maf71
Thank you for your question. We do not currently recommend this FOXP2 Antibody (5C11A8): sc-517261 for IF or IHC(P), because we have not yet tested this antibody in either application. We also do not recommend this antibody for detection of FOXP2 of rat origin, because it has not yet been tested for reactivity in that species. This antibody is recommended for detection of FOXP2 of human origin by WB, IP and ELISA. In general, we would recommend using a starting dilution of 1:50 for IF/IHC, and if you are using formalin-fixation, then antigen retrieval is strongly advised.
Answered by: Technical Support
Date published: 2021-03-01

Is this antibody raised against the same amino acids as the discontinued N-16 antibody?

Asked by: MSMC
Thank you for your question. FOXP2 Antibody (5C11A8): sc-517261 is raised against amino acids 47-287 of FOXP2 of human origin. This is a different epitope than the now discontinued goat polyclonal, FOXP2 Antibody (N-16): sc-21069, that was raised against a short peptide with an epitope mapping within the first 50 amino acids of the N-terminus of FOXP2 of human origin.
Answered by: Technical Support
Date published: 2021-03-01

What is the total volume provided of FOXP2 (5C11A8): sc-517261 monoclonal antibody?

Asked by: jenniferc
Thank you for your question. FOXP2 (5C11A8): sc-517261 is provided as 200 µg in 1 ml total volume.
Answered by: Technical Support
Date published: 2017-03-06
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Rated 5 out of 5 by from Good specificity for FOXP2 in Western BlotAntibody detects over-expressed human FOXP2 in transfected lysate sc-372825. Shown with Cruz Marker molecular weight standards, sc-2035. -SCBT QC
Date published: 2023-09-14
Rated 5 out of 5 by from Works in human cellsThis antibody works well for IF. Dilution is 1:100.
Date published: 2021-05-26
Rated 5 out of 5 by from Works well for IHCThis antibody was generously given to me by the trials program. I found that it works well for IHC at a dilution of 1:50 to 1:250 in both whole mount and cross-sections. It works better in MetOH fixation than in PFA.
Date published: 2018-03-14
Rated 5 out of 5 by from Works well in Nervous Tissue in MouseTried this antibody in central nervous system tissue in mouse, worked well 1:200 with retrieval.
Date published: 2017-06-27
Rated 5 out of 5 by from Great antibody!Works great for IF on brain tissue! Dilution is 1:200.
Date published: 2017-03-20
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FOXP2 抗体 (5C11A8) is rated 5.0 out of 5 by 5.
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