Date published: 2025-9-6

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Flotillin-2 抗体 (A-3): sc-48398

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说明书
  • Flotillin-2抗体(A-3)是小鼠单克隆IgG1 κ, 在5篇文献中引用,规格为200 µg/ml
  • 免疫human物种的flotillin-2的氨基酸151-240
  • 推荐用于 mouse, rat 和 human 来源的Flotillin-2 WB, IP, IF, IHC(P) 和 ELISA检测; 也和以下物种反应,包括: canine
  • 看 Flotillin-2 (B-6): sc-28320,可查看有标记的 Flotillin-2 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP, m-IgG1 BP-HRPm-IgGκ BP-HRP 是 Flotillin-2 抗体 (A-3) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与Flotillin-2 抗体 (A-3) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

Flotillin-2 抗体 (A-3) 是一种小鼠单克隆 IgG1 抗体,可通过各种应用检测小鼠、大鼠和人体样本中的 Flotillin-2,包括免疫印迹 (WB)、免疫沉淀 (IP)、免疫荧光 (IF)、免疫组织化学和酶联免疫吸附试验 (ELISA)。Flotillin-2又称表皮表面抗原,在脂质筏的形成和维持中起着至关重要的作用,脂质筏是特化的膜微域,对信号转导、膜贩运和分子排序等多种细胞过程至关重要。这些脂质筏富含鞘脂和胆固醇,其完整性对细胞功能的正常发挥至关重要。Flotillin-2在不同组织中普遍表达,而Flotillin-1的表达模式较为局限,主要在肾脏细胞、肌肉细胞系和成纤维细胞中表达。Flotillin-2 与其他蛋白质(如 CAP 和 Cbl)的相互作用促进了脂质筏内信号复合物的定位,从而影响了细胞信号通路,包括雌激素对 MAP 激酶级联的快速激活。此外,氟替林素的表达水平还与阿尔茨海默病的进展有关,突显了其在神经退行性过程中的潜在作用。抗氟替林-2 抗体 (A-3) 是研究人员调查脂质筏动态及其对健康和疾病影响的宝贵工具。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Flotillin-2 抗体 (A-3) 参考文献:

  1. Flotillin-1和flotillin-2的内吞作用受Fyn激酶调节。  |  Riento, K., et al. 2009. J Cell Sci. 122: 912-8. PMID: 19258392
  2. reggie-1/flotillin-2和reggie-2/flotillin-1的异质异构化是它们内吞的必要条件。  |  Babuke, T., et al. 2009. Cell Signal. 21: 1287-97. PMID: 19318123
  3. Flotillin-2是一种顶体相关蛋白,参与小鼠精子发生。  |  Wu, Y., et al. 2012. J Biomed Res. 26: 278-87. PMID: 23554761
  4. 人类肠道中的Flotillin-2表达:从健康和炎症性肠病的细胞模型到人体组织。  |  Gauss, A., et al. 2013. Int J Med Sci. 10: 1259-70. PMID: 23983584
  5. Flotillin-2 可调节肺上皮细胞在高氧后由 fas 信号介导的凋亡。  |  Wei, S., et al. 2013. PLoS One. 8: e77519. PMID: 24204853
  6. 使用Flotillin 1-/-、Flotillin 2-/-双基因敲除小鼠研究Flotillins在调节aβ生产中的作用。  |  Bitsikas, V., et al. 2014. PLoS One. 9: e85217. PMID: 24465508
  7. Flotillin-2通过激活NF-κB和PI3K/Akt3信号通路促进鼻咽癌的转移。  |  Liu, J., et al. 2015. Sci Rep. 5: 11614. PMID: 26206082
  8. Litopenaeus vannamei中的膜相关蛋白flotillin-2在WSSV感染中起作用。  |  Shi, H., et al. 2016. Fish Shellfish Immunol. 54: 247-53. PMID: 27079424
  9. Flotillin-2通过抑制鼻咽癌中的miR-33b-5p来激活c-Myc/BCAT1轴,从而促进细胞增殖。  |  Liu, R., et al. 2021. Aging (Albany NY). 13: 8078-8094. PMID: 33744853
  10. Flotillin-2抑制T细胞抗原敏感性和功能性。  |  Moon, S., et al. 2024. JCI Insight. 9: PMID: 39499901

订购信息

产品名称产品编号规格价格数量收藏夹

Flotillin-2 抗体 (A-3)

sc-48398
200 µg/ml
$316.00

Flotillin-2 (A-3): m-IgG Fc BP-HRP 套装

sc-536829
200 µg Ab; 10 µg BP
$354.00

Flotillin-2 (A-3): m-IgGκ BP-HRP 套装

sc-533996
200 µg Ab; 40 µg BP
$354.00

Flotillin-2 (A-3): m-IgG1 BP-HRP 套装

sc-544846
200 µg Ab; 20 µg BP
$354.00

I am using Flotillin-2 (A-3): sc-48398 monoclonal antibody to stain paraffin embedded tissue. Do you recommend antigen retrieval when using this antibody?

Asked by: cjMara
We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by from human for IHCIHC was used on a sample of human, dilution 1:100, this antibody works well
Date published: 2017-09-06
Rated 5 out of 5 by from Beautiful staining!This antibody gives very clear and specific IHC staining. Since it also works beautifully on WB, it's a win-win!
Date published: 2017-01-19
Rated 5 out of 5 by from We are having success in WB using human cancerWe are having success in WB using human cancer and iPS cell lines.
Date published: 2015-10-01
Rated 5 out of 5 by from Good publishable data in WB and IF in ratGood publishable data in WB and IF in rat uterine tissue. -SCBT Publication Review
Date published: 2015-05-13
Rated 5 out of 5 by from Good specificity in WB in AGood specificity in WB in A-375, CCD-1064Sk and MM-142 whole cell lysates and rat adrenal gland tissue extract. -SCBT QC
Date published: 2015-04-15
Rated 5 out of 5 by from Strong band in WB in HeLa whole cell lysateStrong band in WB in HeLa whole cell lysate. -SCBT QC
Date published: 2015-03-25
Rated 5 out of 5 by from Produced beautiful immunoperoxidase cytoplasmicProduced beautiful immunoperoxidase cytoplasmic and membrane staining in formalin fixed, paraffin-embedded human fallopian tube tissue. -SCBT QC
Date published: 2015-03-23
Rated 5 out of 5 by from Robust signal in WB in human transfectedRobust signal in WB in human transfected 293T and CCD-10645SK whole cell lysates. -SCBT QC
Date published: 2015-03-05
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Flotillin-2 抗体 (A-3) is rated 5.0 out of 5 by 8.
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