Fgl2 Antibody (4H5): sc-100276

Fgl2 Antibody (4H5) is a mouse monoclonal IgG2a kappa light chain antibody that detects Fgl2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-Fgl2 antibody (4H5) is available as the non-conjugated form. Fibrinogen-like protein 2 (Fgl2), also known as fibroleukin, plays a crucial role in the immune response and is secreted by T cells, particularly in contexts where thrombosis is significant, such as viral-induced fulminant hepatitis, fetal loss syndrome, and xenograft rejection. Fgl2 is primarily located in the cytoplasm of cytotoxic T-cells, where constitutive expression allows immunosuppressive effects on T cell proliferation and dendritic cell maturation. This localization enables Fgl2 to modulate immune responses effectively, particularly in inflammatory conditions. Additionally, Fgl2 functions as a serine protease, directly cleaving prothrombin to thrombin, which is essential for the coagulation cascade. Fgl2′s ability to influence both immune and coagulation pathways underscores its importance in the pathogenesis of various diseases, including viral-induced hepatitis and Th1 cytokine-induced fetal loss syndrome.

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Fgl2 Antibody (4H5) References:

1. The nucleocapsid protein of murine hepatitis virus type 3 induces transcription of the novel fgl2 prothrombinase gene.  |  Ning, Q., et al. 1999. J Biol Chem. 274: 9930-6. PMID: 10187767
2. Genomic characterization, localization, and functional expression of FGL2, the human gene encoding fibroleukin: a novel human procoagulant.  |  Yuwaraj, S., et al. 2001. Genomics. 71: 330-8. PMID: 11170750
3. Induction of prothrombinase fgl2 by the nucleocapsid protein of virulent mouse hepatitis virus is dependent on host hepatic nuclear factor-4 alpha.  |  Ning, Q., et al. 2003. J Biol Chem. 278: 15541-9. PMID: 12594208
4. Soluble fibrinogen-like protein 2/fibroleukin exhibits immunosuppressive properties: suppressing T cell proliferation and inhibiting maturation of bone marrow-derived dendritic cells.  |  Chan, CW., et al. 2003. J Immunol. 170: 4036-44. PMID: 12682232
5. Endothelial induction of fgl2 contributes to thrombosis during acute vascular xenograft rejection.  |  Ghanekar, A., et al. 2004. J Immunol. 172: 5693-701. PMID: 15100314
6. Region-specific expression and secretion of the fibrinogen-related protein, fgl2, by epithelial cells of the hamster epididymis and its role in disposal of defective spermatozoa.  |  Olson, GE., et al. 2004. J Biol Chem. 279: 51266-74. PMID: 15377663

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Fgl2 Antibody (4H5) has 8 citations in a variety of scientific publications.

Primary antibodies like Anti-Fgl2 Antibody (4H5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Fgl2 Antibody (4H5) Specifications

Alternate Product Name: Fgl2

Product Clone Name: 4H5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 24-124

Epitope Target: Fgl2

Epitope Species: human

Product Reactivity/Detection: Fibrinogen-like protein 2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 8 citations in various scientific publications

Available Conjugates/Forms for Fgl2 Antibody (4H5): N/A