Date published: 2025-9-8

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ferritin light chain 抗体 (D-1): sc-390558

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说明书
  • ferritin light chain抗体(D-1)是小鼠单克隆IgG1 κ, 在11篇文献中引用,规格为200 µg/ml
  • 与human的104-129氨基酸残基的ferritin light chain
  • 推荐用于 mouse, rat 和 human 来源的ferritin light chain WB, IP, IF 和 ELISA检测
  • 看 ferritin light chain (D-9): sc-74513,可查看有标记的 ferritin light chain 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRPm-IgGκ BP-HRP是ferritin light chain Antibody (D-1) 适用于 WB 应用。 的首选辅助检测试剂,这些试剂现与ferritin light chain Antibody (D-1) 打包提供(请参阅下面的订购信息)。

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関連項目

哺乳动物铁蛋白由24个亚基组成,这些亚基由两种类型的多肽链构成,即铁蛋白重链和铁蛋白轻链,它们各自具有独特的功能。铁蛋白重链催化铁储存的第一步,即Fe (II)的氧化,而铁蛋白轻链则促进水铁矿的成核,使Fe (III)得以储存。哺乳动物铁蛋白最突出的作用是为细胞提供铁缓冲能力。除了铁缓冲作用外,重链铁蛋白还通过增加细胞质丝氨酸羟甲基转移酶的表达来参与胸腺嘧啶生物合成的调节,这是MCF-7细胞中胸腺嘧啶合成的限制因素。轻链铁蛋白至少通过两种机制参与白内障的形成,一种是遗传性高铁蛋白血症白内障综合征,其中轻链铁蛋白表达过量,另一种是氧化应激,这是与年龄相关白内障发展的重要因素。编码人类铁蛋白重链的基因位于11号染色体长臂1区3带,而人类铁蛋白轻链基因则位于19号染色体长臂1区3带3亚带至1区3带4亚带。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

ferritin light chain 抗体 (D-1) 参考文献:

  1. 人类eIF3抑制铁蛋白轻链的翻译。  |  Pulos-Holmes, MC., et al. 2019. Elife. 8: PMID: 31414986
  2. 铁蛋白轻链的转录抑制提高了肺腺癌的铁蛋白沉积敏感性  |  Wang, Y., et al. 2021. Front Cell Dev Biol. 9: 719187. PMID: 34765600
  3. JNK/Itch轴介导鼠巨噬细胞中脂多糖诱导的泛素蛋白酶体依赖性铁蛋白轻链降解  |  He, S., et al. 2022. Inflammation. 45: 1089-1100. PMID: 34837126
  4. 特发性肺纤维化患者气道纤毛(FOXJ1+)细胞中铁蛋白轻链含量减少。  |  Wijk, SC., et al. 2022. Cells. 11: PMID: 35326483
  5. 铁蛋白轻链自身抗体是检测肝硬化而非肝癌的血清生物标记物  |  Ren, P., et al. 2022. J Hepatocell Carcinoma. 9: 221-232. PMID: 35378780
  6. SCARA5与铁蛋白轻链结合诱导铁变态反应影响ESCC的增殖和转移  |  Liu, Y., et al. 2022. BMC Cancer. 22: 1304. PMID: 36513999
  7. 髓样细胞特异性铁蛋白轻链缺失不会加剧败血症相关的急性肾损伤。  |  Odum, JD., et al. 2024. Am J Physiol Renal Physiol. 327: F171-F183. PMID: 38779751
  8. 铁蛋白轻链通过HIF1α介导的NF-κB信号通路减轻脑缺血再灌注损伤引起的神经炎症。  |  Jiang, H., et al. 2024. Inflammation.. PMID: 39066965
  9. 脂质运载蛋白-2抑制剂通过增强铁蛋白轻链的表达,在小鼠实验性脑出血后通过抑制小胶质细胞铁死亡来减轻神经损伤。  |  Fei, X., et al. 2024. Biochim Biophys Acta Mol Basis Dis. 1870: 167435. PMID: 39067535
  10. 铁蛋白轻链作为肝细胞肝癌预后的潜在生物标志物。  |  Li, A., et al. 2024. Heliyon. 10: e36040. PMID: 39224384

订购信息

产品名称产品编号规格价格数量收藏夹

ferritin light chain 抗体 (D-1)

sc-390558
200 µg/ml
$316.00

ferritin light chain (D-1): m-IgG Fc BP-HRP 套装

sc-538090
200 µg Ab; 10 µg BP
$354.00

ferritin light chain (D-1): m-IgGκ BP-HRP 套装

sc-535627
200 µg Ab; 40 µg BP
$354.00

ferritin light chain (D-1) 中和勝肽

sc-390558 P
100 µg/0.5 ml
$68.00

What application is the blocking peptide sc-390558 P appropriate for?

Asked by: cjMara
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by from Good, clean and specificGood, clean antibody. It runs a bit higher than expected.
Date published: 2023-01-25
Rated 5 out of 5 by from Nice Western Blot data of ferritin lightNice Western Blot data of ferritin light chain expression in human spleen tissue extract. -SCBT QC
Date published: 2015-03-31
Rated 5 out of 5 by from Good Western Blot data of ferritin lightGood Western Blot data of ferritin light chain expression in non-transfected and human ferritin light chain transfected 293T whole cell lysates. -SCBT QC
Date published: 2013-02-22
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ferritin light chain 抗体 (D-1) is rated 5.0 out of 5 by 3.
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