Fc ε RIα Antibody (1F2A9): sc-517280

Fc ε RIα Antibody (1F2A9) is a mouse monoclonal IgG1 kappa light chain antibody that detects the Fc ε RIα protein of human origin by western blotting (WB), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Fc ε RIα (1F2A9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The IgE Fc Receptor I plays a crucial role in the immune response by binding with high affinity to the Fc region of immunoglobulin E, which is essential for initiating allergic reactions. Upon allergen binding to receptor-bound IgE, a cascade of cellular activation occurs, leading to the release of mediators such as histamines that are responsible for allergy symptoms. Additionally, the IgE Fc Receptor I is involved in the secretion of lymphokines, which are key effectors in hypersensitivity responses. Structurally, the receptor is a tetramer composed of a heavily glycosylated α chain (Fc ε RIα), a β chain, and two disulfide-linked γ chains, with the Fc ε RIα exposed on the cell surface where it contains the IgE binding site. The expression of IgE Fc RI mRNA is highly specific to mast cells and IL-3 dependent myeloid-monocyte precursors, and alternative splicing of the genomic transcript for the α chain has also been documented, highlighting the complexity and regulatory mechanisms involved in its function.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Fc ε RIα Antibody (1F2A9) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Fc ε RIα Antibody (1F2A9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Fc ε RIα Antibody (1F2A9) Specifications

Alternate Product Name: Fc ε RIα

Product Clone Name: 1F2A9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 42-103

Epitope Target: Fc ε RIα

Epitope Species: human

Product Reactivity/Detection: Fc ε RIα

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IF, IHC(P), FCM, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Fc ε RIα Antibody (1F2A9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Fc ε RIα antibody is Fc ε RIα Antibody (X-22): sc-100279.