Date published: 2025-9-7

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EB3 抗体 (7): sc-136405

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说明书
  • EB3 抗体 7 是小鼠单克隆 IgG1 κ,EB3抗体, 在2篇文献中引用,规格为200 µg/ml
  • 免疫human物种的EB3的氨基酸131-222
  • 推荐用于 mouse, rat 和 human 来源的EB3 WB, IP, IF 和 IHC(P)检测
  • 还可偶联琼脂糖 用于IP; 偶联HRP 用于WB, IHC(P) 和ELISA
  • 关于如何获取EB3 (7): sc-136405免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP, m-IgG1 BP-HRPm-IgGκ BP-HRP 是 EB3 抗体 (7) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与EB3 抗体 (7) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

EB3 抗体(7)是一种IgG1 κ型小鼠单克隆EB3抗体(又称EB3抗体),通过WB、IP、IF和IHC(P)检测小鼠、大鼠和人源的EB3蛋白。EB3抗体(7)既有非偶联的抗EB3抗体形式,也有多种偶联的抗EB3抗体形式,包括琼脂糖、辣根过氧化物酶。EB1 (MAPRE2,微管相关蛋白,RP/EB家族成员2,EB2, RP1)可能影响结直肠癌的发生和正常细胞的增殖控制。EB1可能属于中间/早期基因家族,参与TCR下游的信号转导级联。结直肠癌是由正常结肠上皮病理转化为腺瘤性息肉引起的,腺瘤性息肉可成为一种浸润性癌。APC (adenomatous polyposis coli)是一种抑癌基因,其突变是结直肠癌发生的最早事件之一。大多数突变导致APC羧基端缺失。EB1与APC羧基末端区域结合,提示EB1抑制APC在结肠癌中的表达。EB1过表达可能通过影响APC功能和激活β -catenin/TCF通路在人食管鳞状细胞癌(ESCC)的发生发展中发挥作用。EB3与EB1相关,同样与微管细胞骨架相关。EB3主要在中枢神经系统表达,并优先与APCL相关。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

EB3 抗体 (7) 参考文献:

  1. 家族性腺瘤性息肉病和散发性结肠癌中 APC 突变的分子分析。  |  Cottrell, S., et al. 1992. Lancet. 340: 626-30. PMID: 1355210
  2. APC 与新型蛋白质 EB1 结合。  |  Su, LK., et al. 1995. Cancer Res. 55: 2972-7. PMID: 7606712
  3. 人类和小鼠肿瘤中 APC 等全基因的失活。  |  Levy, DB., et al. 1994. Cancer Res. 54: 5953-8. PMID: 7954428
  4. 正常细胞和肿瘤细胞中的 APC 基因产物。  |  Smith, KJ., et al. 1993. Proc Natl Acad Sci U S A. 90: 2846-50. PMID: 8385345
  5. 散发性肝母细胞瘤中 APC 基因的体细胞突变。  |  Oda, H., et al. 1996. Cancer Res. 56: 3320-3. PMID: 8764128
  6. 结直肠癌的分子生物学  |  Gryfe, R., et al. 1997. Curr Probl Cancer. 21: 233-300. PMID: 9438104

订购信息

产品名称产品编号规格价格数量收藏夹

EB3 抗体 (7)

sc-136405
200 µg/ml
$316.00

EB3 (7): m-IgG Fc BP-HRP 套装

sc-528822
200 µg Ab; 10 µg BP
$354.00

EB3 (7): m-IgGκ BP-HRP 套装

sc-521366
200 µg Ab, 40 µg BP
$354.00

EB3 (7): m-IgG1 BP-HRP 套装

sc-543153
200 µg Ab; 20 µg BP
$354.00

EB3 抗体 (7) AC

sc-136405 AC
500 µg/ml, 25% agarose
$416.00

EB3 抗体 (7) HRP

sc-136405 HRP
200 µg/ml
$316.00

Hi I am interested in an antibody against EB3 protein. The product number is sc-136405. I wanna request a free sample, is it possible?

Asked by: Yuhao
Thank you for your question. Please get in touch with our technical support team to arrange a free sample of this antibody.
Answered by: Tech Support Europe
Date published: 2020-12-31

Are there any issues with using sc-136405: EB3 (7) mouse monoclonal primary antibody on mouse samples?

Asked by: TinTin
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent,we recommend using a directly conjugated primary antibody. Please contact our special orders department for pricing and availability of sc-136405 conjugates.
Answered by: Technical Support
Date published: 2017-03-07
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Rated 5 out of 5 by from Good for IFThis EB3 Antibody (7) shows strong specific signal in IF staining in primary rat motor neuron.
Date published: 2017-12-04
Rated 4 out of 5 by from WB publishable data with human HCT116 andWB publishable data with human HCT116 and isogenic CHK2-deficient cells - SCBT Publication Review
Date published: 2013-12-30
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EB3 抗体 (7) is rated 4.5 out of 5 by 2.
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