EAAT4 Antibody (6D9): sc-293344

EAAT4 Antibody (6D9) is a mouse monoclonal IgG1 kappa light chain antibody that detects EAAT4 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). EAAT4 (6D9) antibody is available as a non-conjugated format. EAAT4 plays a crucial role in the central nervous system by functioning as an aspartate/glutamate transporter, predominantly expressed in the cerebellum. EAAT4 is essential for the reuptake of excitatory neurotransmitters L-glutamate and D-aspartate, which helps terminate the postsynaptic action of glutamate and prevents excitotoxicity—a condition that can lead to neuronal damage due to excessive accumulation of these neurotransmitters. The high affinity of EAAT4 for L-aspartate and L-glutamate underscores its importance in maintaining synaptic balance and protecting neurons from potential excitotoxic effects. Additionally, EAAT4′s transport activity is vital for proper cerebellar function, influencing motor coordination and cognitive processes. Understanding the dynamics of EAAT4 and its interactions with other proteins can provide insights into various neurological disorders, making anti-EAAT4 antibody (6D9) a valuable tool for researchers studying excitatory neurotransmission and related pathologies.

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EAAT4 Antibody (6D9) References:

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6. High-affinity glutamate transporters in the rat retina: a major role of the glial glutamate transporter GLAST-1 in transmitter clearance.  |  Rauen, T., et al. 1998. Cell Tissue Res. 291: 19-31. PMID: 9394040