Dynactin p62 Antibody (H-12): sc-55604

Dynactin p62 Antibody (H-12) is a mouse monoclonal IgG2a antibody that detects Dynactin p62 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Dynactin p62 plays a crucial role in the functionality of the dynactin complex, which is essential for the proper functioning of the microtubule-based motor cytoplasmic dynein, a key player in intracellular transport. Dynactin p62 is primarily located in the cytoplasm, where Dynactin p62 exhibits a punctate distribution, and is also found in the nucleus at elevated levels, highlighting Dynactin p62′s importance in cellular organization and transport processes. The presence of Dynactin p62 in the nucleus suggests a potential regulatory role in gene expression or nuclear transport, making Dynactin p62 a significant focus for studies related to cellular dynamics and signaling pathways. Additionally, the p62 subunit contains a highly conserved cysteine-rich motif that facilitates interaction with the actin-related protein 1 (Arp1), further emphasizing Dynactin p62′s structural and functional importance in linking dynein and dynactin to the cortical cytoskeleton. With diverse applications and critical role in cellular processes, anti-Dynactin p62 antibody (H-12) serves as an invaluable tool for researchers investigating the mechanisms of intracellular transport and cytoskeletal dynamics.

The preferred Dynactin p62 antibody is Dynactin p62 Antibody (H-4): sc-55603.