DNAL1 Antibody (AT29E4): sc-517398

DNAL1 Antibody (AT29E4) is a mouse monoclonal IgG2b kappa light chain antibody that detects DNAL1 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Anti-DNAL1 antibody (AT29E4) is available as a non-conjugated format. DNAL1 protein, also known as dynein light chain 1, axonemal, plays a crucial role in dynein complexes function, which are essential for cilia and flagella movement. These structures are vital for various cellular processes, including motility and fluid movement across epithelial surfaces. DNAL1 is composed of 190 amino acids and belongs to dynein light chain LC1-type protein family, characterized by four leucine-rich repeats. DNAL1 interacts directly with DNAH5, a heavy chain component of dynein complex, facilitating assembly and function of motor proteins that drive ciliary movement. DNAL1 is predominantly expressed in testis and other tissues containing motile cilia, underscoring importance in reproductive health and cellular dynamics. DNAL1′s ability to mediate microtubule sliding in axonemes is critical for proper cilia functioning, making DNAL1 a significant target for studies related to ciliary dysfunction and associated diseases.

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DNAL1 Antibody (AT29E4) References:

1. The dynein heavy chain family.  |  Asai, DJ. and Wilkes, DE. 2004. J Eukaryot Microbiol. 51: 23-9. PMID: 15068262
2. High speed sliding of axonemal microtubules produced by outer arm dynein.  |  Seetharam, RN. and Satir, P. 2005. Cell Motil Cytoskeleton. 60: 96-103. PMID: 15605357
3. The offloading model for dynein function: differential function of motor subunits.  |  Lee, WL., et al. 2005. J Cell Biol. 168: 201-7. PMID: 15642746
4. Role of cytoplasmic dynein in the axonal transport of microtubules and neurofilaments.  |  He, Y., et al. 2005. J Cell Biol. 168: 697-703. PMID: 15728192
5. Identification and analysis of axonemal dynein light chain 1 in primary ciliary dyskinesia patients.  |  Horváth, J., et al. 2005. Am J Respir Cell Mol Biol. 33: 41-7. PMID: 15845866
6. NudEL targets dynein to microtubule ends through LIS1.  |  Li, J., et al. 2005. Nat Cell Biol. 7: 686-90. PMID: 15965467
7. The dynein light chain Tctex-1 has a dynein-independent role in actin remodeling during neurite outgrowth.  |  Chuang, JZ., et al. 2005. Dev Cell. 9: 75-86. PMID: 15992542
8. Cytoplasmic dynein nomenclature.  |  Pfister, KK., et al. 2005. J Cell Biol. 171: 411-3. PMID: 16260502
9. Dynein motility: four heads are better than two.  |  McGrath, JL. 2005. Curr Biol. 15: R970-2. PMID: 16332531

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-DNAL1 Antibody (AT29E4) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-DNAL1 Antibody (AT29E4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

DNAL1 Antibody (AT29E4) Specifications

Alternate Product Name: DNAL1

Product Clone Name: AT29E4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 1-190

Epitope Target: DNAL1

Epitope Species: human

Product Reactivity/Detection: DNAL1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, FCM, ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for DNAL1 Antibody (AT29E4): N/A