Date published: 2026-10-19

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Dicer 抗体 (E-7): sc-393328

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说明书
  • Dicer抗体(E-7)是小鼠单克隆IgG2a κ, 在2篇文献中引用,规格为200 µg/ml
  • 特异性抗原位于human物种的Dicer的C-terminus附近的氨基酸1698-1729之间
  • 推荐用于 mouse, rat 和 human 来源的Dicer WB, IP, IF 和 ELISA检测
  • 看 Dicer (F-10): sc-136979,可查看有标记的 Dicer 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP、 2a BP-HRP">m-IgG2a BP-HRP和m-IgGκ BP-HRP是Dicer Antibody (E-7) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与Dicer Antibody (E-7) 打包提供(请参阅下面的订购信息)。
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関連項目

哺乳动物的Dicer是一种与III型RNase相关的蛋白质,在酵母、果蝇和拟南芥中具有同源物。Dicer在其氨基末端含有一个RNA解旋酶基序,包括一个DEXH盒,在其羧基末端含有一个RNase基序。编码人类Dicer的基因位于14q31染色体上。Dicer在脑、心、肝、肺、胰、肾和胎盘中表达,并在RNA干扰途径中发挥作用。Dicer将大约70bp的短发夹RNA前体切割成21-23bp的dsRNAs,这些dsRNAs选择性地靶向同源RNA的破坏。Dicer定位于哺乳动物细胞的细胞质中。具体来说,它与内质网中的钙网蛋白共定位。尽管Dicer对RNA的切割不依赖于ATP,但这种酶快速周转所需的产物释放可能归因于ATP。免疫沉淀研究表明,Dicer与eIF2C翻译起始因子的PIWI结构域形成复合物。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Dicer 抗体 (E-7) 参考文献:

  1. Dicer在女性生育中的作用。  |  Luense, LJ., et al. 2009. Trends Endocrinol Metab. 20: 265-72. PMID: 19646895
  2. 切割染色体:Dicer 在细胞凋亡中的意外作用  |  Harry, BL., et al. 2010. Cell Cycle. 9: 4772-3. PMID: 21150320
  3. Dicer/RIG-I样ATP酶跨物种检测病毒RNA。  |  Paro, S., et al. 2015. Curr Opin Immunol. 32: 106-13. PMID: 25658360
  4. Dicer-2通过细胞质多聚腺苷酸化促进mRNA激活。  |  Coll, O., et al. 2018. RNA. 24: 529-539. PMID: 29317541
  5. Dicer调节蜜蜂中Nosema ceranae的增殖。  |  Huang, Q., et al. 2019. Insect Mol Biol. 28: 74-85. PMID: 30171639
  6. Dicer在能量稳态调节、结构修饰和细胞分布方面的功能。  |  Tong, X., et al. 2020. Int J Endocrinol. 2020: 6420816. PMID: 32774363
  7. 脂肪组织中 DICER 水平的动态变化控制着对运动的代谢适应。  |  Brandão, BB., et al. 2020. Proc Natl Acad Sci U S A. 117: 23932-23941. PMID: 32900951
  8. Dicer缺陷会抑制增殖,但增强巨噬细胞对胶质母细胞瘤的抗肿瘤作用。  |  Liu, YQ., et al. 2022. Oncogene. 41: 3791-3803. PMID: 35764885
  9. 果蝇 Dicer-2-Loqs-PD 处理 dsRNA 的结构见解。  |  Su, S., et al. 2022. Nature. 607: 399-406. PMID: 35768513
  10. 伴侣介导的自噬降解 Dicer,促进乳腺癌转移。  |  Su, CM., et al. 2023. J Cell Physiol. 238: 829-841. PMID: 36815383

订购信息

产品名称产品编号规格价格数量收藏夹

Dicer 抗体 (E-7)

sc-393328
200 µg/ml
$322.00

Dicer (E-7): m-IgG Fc BP-HRP 套装

sc-538190
200 µg Ab; 10 µg BP
$361.00

Dicer (E-7): m-IgGκ BP-HRP 套装

sc-535754
200 µg Ab; 40 µg BP
$361.00

Dicer (E-7): m-IgG2a BP-HRP 套装

sc-548228
200 µg Ab; 10 µg BP
$361.00

Dicer (E-7) 中和勝肽

sc-393328 P
100 µg/0.5 ml
$69.00

What application is the blocking peptide sc-393328 P appropriate for?

Asked by: AbPolly
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by DefinitelyNotMatt from Great Antibody for WBThis antibody is well-cited for a variety of applications including WB, IP, IF, and ELISA. Strong, clear signal with little to no background. Works well in a variety of species including mouse, rat, and human samples.
Date published: 2017-01-26
Rated 5 out of 5 by MS from Satisfactory Western Blot data of Dicer expressionSatisfactory Western Blot data of Dicer expression in NIH/3T3 whole cell lysate and K-562 and Jurkat nuclear extracts. -SCBT QC
Date published: 2015-04-17
Rated 5 out of 5 by TS from Produced positive Western Blot data of DicerProduced positive Western Blot data of Dicer expression in NIH/3T3 and KNRK whole cell lysates. -SCBT QC
Date published: 2014-01-15
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Dicer 抗体 (E-7) is rated 5.0 out of 5 by 3.
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