Date published: 2025-9-8

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Decorin 抗体 (9XX): sc-73896

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说明书
  • Decorin 抗体 9XX 是小鼠单克隆 IgG1 κ,Decorin抗体, 在21篇文献中引用,规格为50 µg/0.5 ml
  • 免疫human物种的Decorin的氨基酸17-172
  • 推荐用于 human 来源的Decorin WB, IP, IF, IHC(P) 和 ELISA检测
  • 关于如何获取Decorin (9XX): sc-73896免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRPm-IgG1 BP-HRP 是 Decorin 抗体 (9XX) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与Decorin 抗体 (9XX) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

Decorin抗体(9XX)是一种小鼠单克隆IgG1 kappa轻链抗体,可通过蛋白质印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)、石蜡包埋切片免疫组织化学(IHCP)和酶联免疫吸附测定(ELISA)检测人源性Decorin蛋白。抗Decorin抗体(9XX)以非结合形式提供。Decorin是一种重要的富含亮氨酸的小蛋白多糖(SLRP),通过与I、II和IV型胶原蛋白相互作用,在细胞外基质(ECM)中发挥重要作用,从而影响胶原纤维的组装和稳定性。 Decorin由一种核心蛋白组成,该蛋白具有十个富含亮氨酸的重复序列,这些重复序列对于结构完整性和功能性至关重要,因为它们为糖基化提供了位点,并且两侧是稳定二硫键的环。这种独特的结构使 Decorin 不仅能够与胶原蛋白结合,还能与各种生长因子和细胞间基质分子(如纤维粘连蛋白和血栓素)结合,从而促进重要的细胞过程。此外,Decorin 还是转化生长因子β(TGFβ)的负调节因子,而后者对于调节细胞生长和分化至关重要。人类 Decorin 基因位于 12q21.33 染色体上,编码一种 359 个氨基酸的蛋白质,使 Decorin 成为维持组织稳态和调节炎症反应的重要成分,特别是在表达可能改变的关节疾病中。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Decorin 抗体 (9XX) 参考文献:

  1. 转化生长因子-beta 和 p-21:Decolin 介导的抑制肿瘤生长的多个分子靶点。  |  Ständer, M., et al. 1999. Cell Tissue Res. 296: 221-7. PMID: 10382266
  2. Decorin:一种抑制肿瘤生长的生长因子拮抗剂。  |  Järvinen, TA. and Prince, S. 2015. Biomed Res Int. 2015: 654765. PMID: 26697491
  3. Decorin 交互网络:对 Decorin 结合伙伴及其多功能性的全面分析。  |  Gubbiotti, MA., et al. 2016. Matrix Biol. 55: 7-21. PMID: 27693454
  4. 蜕皮素介导的癌上抑制--未来人类上皮癌的一种潜在辅助疗法。  |  Sainio, AO. and Järveläinen, HT. 2019. Br J Pharmacol. 176: 5-15. PMID: 29488209
  5. 装饰素调节软骨细胞外基质微机械生物学。  |  Chery, DR., et al. 2021. Matrix Biol. 96: 1-17. PMID: 33246102
  6. 子宫内膜异位症中 Decorin 和 VEGF 之间的关系。  |  Aydin, GA., et al. 2021. J Coll Physicians Surg Pak. 31: 1285-1290. PMID: 34689484
  7. 从克隆的 cDNA 中推导出细胞外基质蛋白多糖核心蛋白的一级结构。  |  Krusius, T. and Ruoslahti, E. 1986. Proc Natl Acad Sci U S A. 83: 7683-7. PMID: 3484330
  8. Decorin 和 Biglycan 信号在肿瘤发生中的作用  |  Diehl, V., et al. 2021. Front Oncol. 11: 801801. PMID: 34917515
  9. 通过调控多种受体和不同的信号通路,去甲斑蝥素具有抑制肿瘤的作用。  |  Xie, C., et al. 2022. Am J Physiol Cell Physiol. 322: C554-C566. PMID: 35171698
  10. CSF decorin的增加可预测阿尔茨海默氏症Aβ淀粉样变性引起的大脑病理变化。  |  Jiang, R., et al. 2022. Acta Neuropathol Commun. 10: 96. PMID: 35787306
  11. 在一例严重/致命的成骨不全症病例中,小蛋白多糖decolin表达不足。  |  Dyne, KM., et al. 1996. Am J Med Genet. 63: 161-6. PMID: 8723103
  12. γ干扰素和肿瘤坏死因子α对培养人软骨细胞中编码 aggrecan, biglycan 和 decorin 核心蛋白的基因表达的影响。  |  Dodge, GR., et al. 1998. Arthritis Rheum. 41: 274-83. PMID: 9485085

订购信息

产品名称产品编号规格价格数量收藏夹

Decorin 抗体 (9XX)

sc-73896
50 µg/0.5 ml
$316.00

Decorin (9XX): m-IgG Fc BP-HRP 套装

sc-539507
50 µg Ab; 10 µg BP
$354.00

Decorin (9XX): m-IgG1 BP-HRP 套装

sc-541532
50 µg Ab; 20 µg BP
$354.00

I am using Decorin Antibody (9XX): sc-73896 to stain paraffin embedded tissue. Do you recommend antigen retrieval when using this antibody?

Asked by: TinTin
We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining.
Answered by: Technical Support 7
Date published: 2017-01-13

I am using the LiCor/Odyssey system. Which secondary antibody do you recommend using with Decorin (9XX):sc-73896?

Asked by: TinTin
We recommend using one of our our exclusive Mouse IgG Binding Proteins (m-IgGκ) conjugated to CFL 680 or CFL 790. They are suitable for use with Near-Infrared (NIR) detection systems, such as LI-COR/Odyssey and other comparable systems. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
Answered by: Technical Support 7
Date published: 2017-01-13
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Rated 1 out of 5 by from It does not workFailed detection on WB and IF. Our cells (CAFs) have high expression as observed by qPCR. We would like a reimbursement or a change to another decorin antibody.
Date published: 2020-07-13
Rated 5 out of 5 by from 功能很出色买了这个产品就出结果了,简直太棒了 很喜欢这个公司的试剂,。。。。。。。。
Date published: 2018-10-16
Rated 5 out of 5 by from Good Decorin antibodyThis antibody shows good detection of Decorin transfected samples in Western Blot.
Date published: 2017-01-18
Rated 3 out of 5 by from WB with none spicific bandWe could see a dim approximate 55kd WB band but with other none specific bands
Date published: 2016-12-30
Rated 3 out of 5 by from Performed immunohistochemical analysis usingPerformed immunohistochemical analysis using rabbit Cornea Protein Lysates. -SCBT Publication Review
Date published: 2015-06-24
Rated 4 out of 5 by from Used for IF in SLRPs and HTS cellsUsed for IF in SLRPs and HTS cells. -SCBT Publication Review
Date published: 2015-06-06
Rated 4 out of 5 by from 1:50 dilution used for ICC with mesenchymal1:50 dilution used for ICC with mesenchymal stem cells. -SCBT Publication Review
Date published: 2015-05-12
Rated 4 out of 5 by from Published western blot data using caninePublished western blot data using canine heart valves (mitral valves). -SCBT Publication Review
Date published: 2015-02-10
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Decorin 抗体 (9XX) is rated 3.6 out of 5 by 9.
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