Dab2 Antibody (C-1): sc-390942

Dab2 Antibody (C-1) is a mouse monoclonal IgG2b antibody that detects Dab2 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Dab2, also known as DOC-2, is a mitogen-responsive phosphoprotein that plays a crucial role in cellular signaling and growth regulation. Dab2 is primarily located in the cytoplasm and interacts with the SH3 domain of GRB2, suggesting that Dab2 may act as a negative regulator of growth, thereby influencing cell proliferation and differentiation. Dab2′s ability to modulate signaling pathways is essential for maintaining cellular homeostasis and preventing uncontrolled cell growth, which can lead to various diseases, including cancer. Additionally, Dab2 participates in the endocytic pathway, helping in the internalization of growth factor receptors, further underscoring Dab2′s importance in regulating cellular responses to external stimuli. With versatile applications and a critical role in cellular processes, anti-Dab2 antibody (C-1) serves as an invaluable tool for researchers studying developmental biology and signaling pathways.

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Dab2 Antibody (C-1) References:

1. The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2.  |  Wang, Z., et al. 2002. J Biol Chem. 277: 12622-31. PMID: 11812785
2. Characterization of a novel negative regulator (DOC-2/DAB2) of c-Src in normal prostatic epithelium and cancer.  |  Zhou, J., et al. 2003. J Biol Chem. 278: 6936-41. PMID: 12473651
3. Mutually dependent localization of megalin and Dab2 in the renal proximal tubule.  |  Nagai, J., et al. 2005. Am J Physiol Renal Physiol. 289: F569-76. PMID: 15870384
4. Akt recruits Dab2 to albumin endocytosis in the proximal tubule.  |  Koral, K., et al. 2014. Am J Physiol Renal Physiol. 307: F1380-9. PMID: 25253241
5. Dab2, a negative regulator of DC immunogenicity, is an attractive molecular target for DC-based immunotherapy.  |  Ahmed, MS., et al. 2015. Oncoimmunology. 4: e984550. PMID: 25949867
6. Rapid Downregulation of DAB2 by Toll-Like Receptor Activation Contributes to a Pro-Inflammatory Switch in Activated Dendritic Cells.  |  Figliuolo da Paz, V., et al. 2019. Front Immunol. 10: 304. PMID: 30873168
7. Disabled Homolog 2 (DAB2) Protein in Tumor Microenvironment Correlates with Aggressive Phenotype in Human Urothelial Carcinoma of the Bladder.  |  Itami, Y., et al. 2020. Diagnostics (Basel). 10: PMID: 31968685
8. Epstein-Barr virus miR-BART1-3p suppresses apoptosis and promotes migration of gastric carcinoma cells by targeting DAB2.  |  Min, K., et al. 2020. Int J Biol Sci. 16: 694-707. PMID: 32025216
9. The effect of eight weeks of moderate and high intensity aerobic training on the gene expression of Mir-145, Wnt3a and Dab2 in the heart tissue of type 2 diabetic rats.  |  Rezaei, S., et al. 2021. J Diabetes Metab Disord. 20: 1597-1604. PMID: 34900811
10. Sporothrix schenckii regulates macrophage inflammatory responses via the c-JUN-induced Dab2 transcription.  |  Zhao, S., et al. 2022. Exp Dermatol. 31: 1330-1340. PMID: 35441732

The preferred Dab2 antibody is Dab2 Antibody (E-11): sc-136964.