cyclin T1 Antibody (F-8): sc-515067
- cyclin T1 Antibody (F-8) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 691-716 at the C-terminus of cyclin T1 of human origin
- recommended for detection of cyclin T1 of human origin by WB, IP, IF and ELISA
- See cyclin T1 (E-3): sc-271348 for cyclin T1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for cyclin T1 Antibody (F-8) for WB applications. These reagents are now offered in bundles with cyclin T1 Antibody (F-8) (see ordering information below).
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Cyclin T1 Antibody (F-8) is a mouse monoclonal IgG2a antibody that detects cyclin T1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Cyclin T1 plays a crucial role in the regulation of transcription elongation by forming a complex with cyclin-dependent kinase 9 (Cdk9), which is essential for the phosphorylation of the C-terminal domain of RNA polymerase II. This phosphorylation is vital for the transition of RNA polymerase II from transcription initiation to elongation, thereby facilitating the production of mRNA. The interaction between cyclin T1 and the HIV-1 Tat protein is particularly significant, as cyclin T1 enhances Tat′s ability to bind to the viral TAR RNA, promoting the recruitment of the cyclin T1/Cdk9 complex to RNA polymerase II. This mechanism underscores cyclin T1′s importance not only in cellular transcription processes but also in viral replication, highlighting cyclin T1′s potential as a target for therapeutic interventions in diseases associated with dysregulated transcription. Anti-cyclin T1 antibody (F-8) is an invaluable tool for researchers studying transcriptional regulation and its implications in both normal physiology and disease states.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
cyclin T1 Antibody (F-8) | sc-515067 | 200 µg/ml | $322.00 | |||
cyclin T1 Antibody (F-8): m-IgG Fc BP-HRP Bundle | sc-538746 | 200 µg Ab; 10 µg BP | $361.00 | |||
cyclin T1 Antibody (F-8): m-IgGκ BP-HRP Bundle | sc-536411 | 200 µg Ab; 40 µg BP | $361.00 | |||
cyclin T1 Antibody (F-8): m-IgG2a BP-HRP Bundle | sc-548392 | 200 µg Ab; 10 µg BP | $361.00 | |||
cyclin T1 (F-8) Neutralizing Peptide | sc-515067 P | 100 µg/0.5 ml | $69.00 |