Coronin 1A Antibody (14.1): sc-100925

Coronin 1A Antibody (14.1) is a mouse monoclonal IgG2a kappa light chain antibody that detects Coronin 1A of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-Coronin 1A antibody (14.1) is available as a non-conjugated format. Coronin 1A, also known as CORO1A, TACO, and p57, plays a crucial role in regulating cell motility and cytoskeletal dynamics by localizing to submembranous areas and interacting with actin filaments. Coronin 1A is essential for forming coiled coil-mediated homotrimeric complexes, which are vital for early phagosome formation, thereby influencing immune responses. Additionally, Coronin 1A participates in phosphorylation processes that modulate activity and interactions with other proteins, such as Coronin 1B, which regulates leading edge dynamics in fibroblasts. The intricate balance of these interactions is critical for maintaining cellular functions, including migration and morphology, making Coronin 1A a significant player in both normal physiology and pathological conditions.

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Coronin 1A Antibody (14.1) References:

1. Coronin localizes to leading edges and is involved in cell spreading and lamellipodium extension in vertebrate cells.  |  Mishima, M. and Nishida, E. 1999. J Cell Sci. 112 (Pt 17): 2833-42. PMID: 10444378
2. Oligomerization, F-actin interaction, and membrane association of the ubiquitous mammalian coronin 3 are mediated by its carboxyl terminus.  |  Spoerl, Z., et al. 2002. J Biol Chem. 277: 48858-67. PMID: 12377779
3. Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1.  |  Yoon, HG., et al. 2003. EMBO J. 22: 1336-46. PMID: 12628926
4. Coronin 7, the mammalian POD-1 homologue, localizes to the Golgi apparatus.  |  Rybakin, V., et al. 2004. FEBS Lett. 573: 161-7. PMID: 15327992
5. Association of the leukocyte plasma membrane with the actin cytoskeleton through coiled coil-mediated trimeric coronin 1 molecules.  |  Gatfield, J., et al. 2005. Mol Biol Cell. 16: 2786-98. PMID: 15800061
6. Coronin 3 and its role in murine brain morphogenesis.  |  Hasse, A., et al. 2005. Eur J Neurosci. 21: 1155-68. PMID: 15813925
7. Coronin-1 function is required for phagosome formation.  |  Yan, M., et al. 2005. Mol Biol Cell. 16: 3077-87. PMID: 15829569
8. Coronin proteins as multifunctional regulators of the cytoskeleton and membrane trafficking.  |  Rybakin, V. and Clemen, CS. 2005. Bioessays. 27: 625-32. PMID: 15892111
9. Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility.  |  Cai, L., et al. 2005. J Biol Chem. 280: 31913-23. PMID: 16027158
10. Coronin-1A: immune deficiency in humans and mice.  |  Punwani, D., et al. 2015. J Clin Immunol. 35: 100-7. PMID: 25666293
11. Emergent Role of Coronin-1a in Neuronal Signaling.  |  Martorella, M., et al. 2017. Vitam Horm. 104: 113-131. PMID: 28215292
12. Coronin 1A facilitates calcium mobilization and promotes astrocyte reactivity in HIV-1 neuropathogenesis.  |  Pandey, HS., et al. 2022. FASEB Bioadv. 4: 254-272. PMID: 35415462

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Coronin 1A Antibody (14.1) has 12 citations in a variety of scientific publications.

Primary antibodies like Anti-Coronin 1A Antibody (14.1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Coronin 1A Antibody (14.1) Specifications

Alternate Product Name: TACO, CORO1A

Product Clone Name: 14.1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 360-462

Epitope Target: Coronin 1A

Epitope Species: human

Product Reactivity/Detection: Coronin 1A

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 12 citations in various scientific publications

Available Conjugates/Forms for Coronin 1A Antibody (14.1): N/A