Date published: 2025-9-6

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Cdk6 抗体 (DCS-90): sc-56282

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说明书
  • Cdk6抗体(DCS-90)是小鼠单克隆IgG1 κ, 在11篇文献中引用,规格为200 µg/ml
  • 针对全长Cdk6,human起源
  • 推荐用于 mouse, rat 和 human 来源的Cdk6 WB, IP, IF 和 ELISA检测; 不会与 other Cdk types产生交联反应
  • 看 Cdk6 (DCS-83): sc-53638,可查看有标记的 Cdk6 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP是Cdk6 Antibody (DCS-90) 适用于 WB 应用。 的首选辅助检测试剂。该试剂现与Cdk6 Antibody (DCS-90) 搭配使用(请参阅下面的订购信息)。

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関連項目

细胞周期进程部分地由细胞周期蛋白和细胞周期蛋白依赖性激酶(Cdks)家族控制。Cdk蛋白与细胞周期蛋白协同作用,磷酸化参与细胞周期每个阶段的关键底物。另一个蛋白质家族,Cdk抑制剂,也通过与细胞周期蛋白-Cdk复合物结合并调节它们的活性,在调节细胞周期中发挥作用。已经鉴定出几种Cdk蛋白,包括Cdk2-Cdk8、PCTAIRE-1-PCTAIRE-3、PITALRE和PITSLRE。已知Cdk6与细胞周期蛋白D1、D2和D3结合,并参与细胞周期的G1/S转换。已经鉴定出多种Cdk6抑制剂,包括p18和p19。这些抑制剂与游离和复合的Cdk6结合,并且它们抑制细胞周期蛋白D结合的Cdk6的活性。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Cdk6 抗体 (DCS-90) 参考文献:

  1. 阿贝卡西布(一种CDK4和CDK6抑制剂)对乳腺癌、非小细胞肺癌和其他实体瘤患者的疗效和安全性。  |  Patnaik, A., et al. 2016. Cancer Discov. 6: 740-53. PMID: 27217383
  2. MONARCH 1:CDK4 和 CDK6 抑制剂 Abemaciclib 单药治疗难治性 HR+/HER2- 转移性乳腺癌患者的 II 期研究。  |  Dickler, MN., et al. 2017. Clin Cancer Res. 23: 5218-5224. PMID: 28533223
  3. YAP通过调节CDK6信号传导来防止星形胶质细胞的过早衰老和阿尔茨海默病的认知能力下降。  |  Xu, X., et al. 2021. Aging Cell. 20: e13465. PMID: 34415667
  4. 蛋白质组学分析揭示了CDK6上调是多发性骨髓瘤患者对来那度胺的一种靶向耐药机制。  |  Ng, YLD., et al. 2022. Nat Commun. 13: 1009. PMID: 35197447
  5. Fbxo7 可促进 Cdk6 的活性,从而抑制 T 细胞中的 PFKP 和糖酵解。  |  Harris, R., et al. 2022. J Cell Biol. 221: PMID: 35670764
  6. 靶向蛋白酪氨酸磷酸酶治疗 CDK6 诱导的免疫疗法耐药性  |  Gao, X., et al. 2023. Cell Rep. 42: 112314. PMID: 37000627
  7. CDK4和CDK6阻断引起的DNA损伤通过cGAS-STING途径触发抗肿瘤免疫反应。  |  Fan, H., et al. 2023. Commun Biol. 6: 1041. PMID: 37833461
  8. 广谱激酶谱分析发现CDK6上调是肝细胞癌对仑伐替尼耐药的驱动因素。  |  Leung, CON., et al. 2023. Nat Commun. 14: 6699. PMID: 37872167
  9. IGF2BP2通过招募EIF4A1来促进m6A修饰的CDK6翻译起始过程,从而驱动三阴性乳腺癌细胞周期的进展。  |  Xia, T., et al. 2024. Adv Sci (Weinh). 11: e2305142. PMID: 37983610
  10. 激素受体阳性乳腺癌治疗中CDK4/CDK6抑制剂的敏感性和耐药性机制。  |  Glaviano, A., et al. 2024. Drug Resist Updat. 76: 101103. PMID: 38943828

订购信息

产品名称产品编号规格价格数量收藏夹

Cdk6 抗体 (DCS-90)

sc-56282
200 µg/ml
$316.00

Cdk6 (DCS-90): m-IgG Fc BP-HRP 套装

sc-551937
200 µg Ab; 10 µg BP
$354.00

Are there any issues with using sc-56282: Cdk6 (DCS-90) mouse monoclonal primary antibody on mouse samples?

Asked by: Cweed
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent,we recommend using a directly conjugated primary antibody. Please contact our special orders department for pricing and availability of sc-56282 conjugates.
Answered by: Technical Support
Date published: 2017-03-07
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Rated 4 out of 5 by from Performs well in WesternPerforms well in Western, good signal with A375-STAT1, FM55P, FM55M1, IGR39, IGR37, MeWo, SK-Mel30, Jurkat and MT4 -SCBT Publication Review
Date published: 2015-04-13
Rated 4 out of 5 by from The antibody works well for Western blottingThe antibody works well for Western blotting detecting endogenous Cdk6 from K-562 and Jurkat whole cell lysates. -SCBT QC
Date published: 2014-09-21
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Cdk6 抗体 (DCS-90) is rated 4.0 out of 5 by 2.
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