CD71/TFRC/Transferrin Receptor Antibody (R17217): sc-52504

CD71 Antibody (R17217) is a rat monoclonal IgG2a antibody that detects CD71 in mouse samples through flow cytometry (FCM). CD71, also known as the transferrin receptor (TFR), is a type II membrane glycoprotein that plays a crucial role in iron homeostasis by facilitating cellular uptake of iron through receptor-mediated endocytosis. CD71 exists as a disulfide-linked homodimer, composed of two identical subunits, and binds to transferrin, a serum iron-transport protein, allowing cells to acquire iron necessary for various biological processes, including hemoglobin synthesis and cellular respiration. CD71 is typically expressed at high levels on all proliferating cells, reticulocytes, and erythroid precursors, while CD71 expression is upregulated in activated lymphocytes, monocytes, and macrophages, highlighting CD71′s importance in immune responses and cellular proliferation. CD71 is present on most dividing cells and brain endothelium, indicating CD71′s widespread role in both hematopoiesis and neurobiology. Understanding CD71 function is vital, as mutations in the related transferrin receptor TFR2 can lead to hereditary hemochromatosis type III, an iron overload disorder, emphasizing the significance of iron regulation in health and disease. Anti-CD71 antibody (R17217) is an essential tool for researchers studying iron metabolism and its implications in various physiological and pathological conditions.

The preferred CD71/TFRC/Transferrin Receptor antibody is CD71/TFRC/Transferrin Receptor Antibody (3B8 2A1): sc-32272.