c-Fms/CSF-1R Antibody (0.N.178): sc-70451
- c-Fms/CSF-1R Antibody (0.N.178) is a rat monoclonal IgG1 provided at 200 µg/ml
- recommended for detection of c-Fms gp130 and gp150 of mouse, rat and human origin by WB and IP
- See c-Fms/CSF-1R (B-8): sc-46662 for c-Fms/CSF-1R antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for c-Fms/CSF-1R Antibody (0.N.178). This work is in progress.
QUICK LINKS
SEE ALSO...
c-Fms/CSF-1R Antibody (0.N.178) is a rat monoclonal IgG1 antibody that detects c-Fms/CSF-1R in mouse, rat, and human samples through applications such as western blotting (WB) and immunoprecipitation (IP). c-Fms/CSF-1R, also known as macrophage colony-stimulating factor receptor (M-CSFR), FIM2, or CD115, is a transmembrane tyrosine kinase receptor that plays a crucial role in the growth and differentiation of myeloid cells. c-Fms/CSF-1R is encoded by the c-Fms proto-oncogene and is predominantly expressed in mononuclear phagocytes, oocytes, decidual cells, trophoblastic cells, and certain myoblasts. c-Fms/CSF-1R functions by mediating the actions of macrophage colony-stimulating factor (M-CSF), a glycoprotein essential for the proliferation and differentiation of mononuclear phagocytes, including osteoclasts. M-CSF is also a key player in the inflammatory response, regulating the release of proinflammatory cytokines from macrophages, which underscores its significance in both immune response and tissue homeostasis. anti-c-Fms/CSF-1R antibody (0.N.178) is an invaluable tool for researchers studying myeloid cell biology and the mechanisms underlying inflammation and immune regulation.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
c-Fms/CSF-1R Antibody (0.N.178) References:
- Colony-stimulating factor-1 impairs both proliferation and differentiation signals of erythropoietin during the commitment of bipotential NFS-60 cell line to the monocytic lineage. | Pawlak, G., et al. 1999. Exp Hematol. 27: 797-805. PMID: 10340394
- Colony-stimulating factor-1 and its receptor do not have a role in the pathogenesis of uterine sarcomas. | Anderson, PS., et al. 1999. Gynecol Oncol. 74: 202-7. PMID: 10419732
- A novel 110 kDa form of myosin XVIIIA (MysPDZ) is tyrosine-phosphorylated after colony-stimulating factor-1 receptor signalling. | Cross, M., et al. 2004. Biochem J. 380: 243-53. PMID: 14969583
- A proteomics strategy for the enrichment of receptor-associated complexes. | Cross, M., et al. 2005. Proteomics. 5: 4754-63. PMID: 16267818
- Conditional deletion of the colony stimulating factor-1 receptor (c-fms proto-oncogene) in mice. | Li, J., et al. 2006. Genesis. 44: 328-35. PMID: 16823860
- Selective inhibition of PGE2 production in cells transfected with c-fms encoded CSF-1 receptor genes by the tyrosine kinase inhibitor, ST638. | Puri, J., et al. 1991. Agents Actions. 33: 314-7. PMID: 1950818
- Colony-stimulating factor-1 (CSF-1) directly inhibits receptor activator of nuclear factor-{kappa}B ligand (RANKL) expression by osteoblasts. | Wittrant, Y., et al. 2009. Endocrinology. 150: 4977-88. PMID: 19819976
- Inhibition of colony-stimulating factor-1 activity by monoclonal antibodies to the human CSF-1 receptor. | Sherr, CJ., et al. 1989. Blood. 73: 1786-93. PMID: 2540857
- Recognition of activated CSF-1 receptor in breast carcinomas by a tyrosine 723 phosphospecific antibody. | Flick, MB., et al. 1997. Oncogene. 14: 2553-61. PMID: 9191055
- The role of colony-stimulating factor 1 and its receptor in the etiopathogenesis of endometrial adenocarcinoma. | Smith, HO., et al. 1995. Clin Cancer Res. 1: 313-25. PMID: 9815987
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
c-Fms/CSF-1R Antibody (0.N.178) | sc-70451 | 200 µg/ml | $322.00 |