c-Fgr Antibody (C-11): sc-514251

c-Fgr Antibody (C-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects c-Fgr p55 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). c-Fgr is a member of the Src family of non-receptor tyrosine kinases, which play a crucial role in various cellular processes, including proliferation, differentiation, motility, and adhesion. c-Fgr protein, consisting of 529 amino acids, is primarily located in the cytoplasm and is involved in signaling pathways that regulate immune responses and hematopoiesis. Proper functioning of c-Fgr protein is essential for maintaining cellular homeostasis and responding to external stimuli. c-Fgr protein interacts with several specific proteins, including adapter protein Grb2 and phosphatase SHP-1, which are vital for mediating downstream signaling events. Structural features of c-Fgr, including amino-terminal cell membrane anchor and SH3 and SH2 domains, facilitate modular association and activation, allowing signal transduction. anti-c-Fgr antibody (C-11) is an invaluable tool for researchers studying intricate signaling networks involving c-Fgr and its role in various physiological and pathological processes.

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c-Fgr Antibody (C-11) References:

1. Early activation of the proto-oncogene c-fgr during Epstein-Barr virus immortalization.  |  Okano, M., et al. 1992. Cancer Lett. 64: 11-5. PMID: 1317747
2. A polymorphic microsatellite repeat is located close to the promoter region of the c-fgr proto-oncogene (FGR) at chromosome 1p36.2-p36.1.  |  Patel, MS., et al. 1992. Hum Mol Genet. 1: 65. PMID: 1339476
3. Structure of the complete human c-fgr proto-oncogene and identification of multiple transcriptional start sites.  |  Patel, M., et al. 1990. Oncogene. 5: 201-6. PMID: 1690869
4. Human chronic lymphocytic leukemia cells regularly express mRNAs of the protooncogenes lck and c-fgr.  |  Abts, H., et al. 1991. Leuk Res. 15: 987-97. PMID: 1961014
5. Regulation of c-fgr proto-oncogene expression in Epstein-Barr virus infected B-cell lines.  |  Patel, M., et al. 1990. Int J Cancer. 45: 342-6. PMID: 2154410
6. Regulation of c-fgr proto-oncogene expression in Burkitt's lymphoma cells: effect of interferon treatment and relationship to EBV status and c-myc mRNA levels.  |  Sharp, NA., et al. 1989. Oncogene. 4: 1043-6. PMID: 2548145
7. Expression of the c-fgr related transcripts in Epstein-Barr virus-associated malignancies.  |  Klein, C., et al. 1988. Int J Cancer. 42: 29-35. PMID: 2839429
8. Structure, expression, and chromosomal location of the human c-fgr gene.  |  Nishizawa, M., et al. 1986. Mol Cell Biol. 6: 511-7. PMID: 3023853
9. Retinoic acid induces changes in c-fgr proto-oncogene mRNA levels in Burkitt's lymphoma cells.  |  Faulkner, L., et al. 1993. Immunobiology. 188: 460-8. PMID: 8244449
10. Sequence specificity of C-terminal Src kinase (CSK)--a comparison with Src-related kinases c-Fgr and Lyn.  |  Ruzzene, M., et al. 1997. Eur J Biochem. 246: 433-9. PMID: 9208935

The preferred c-Fgr antibody is c-Fgr Antibody (D-6): sc-74542.