Bcl-6 Antibody (PG-B6P): sc-56625

Bcl-6 Antibody (PG-B6P) is a mouse monoclonal IgG1 antibody designed to detect BCL6 protein, also known as BCL6 transcription repressor, across mouse, rat, and human species using western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF) techniques. BCL6 monoclonal antibody (PG-B6P) targets an epitope spanning amino acids 3-484 at the N-terminus of human BCL6 protein, ensuring precise and reliable binding. BCL6 is a crucial transcriptional repressor predominantly located in the nucleus, where BCL6 binds to Stat recognition-like DNA elements to regulate gene expression. Nuclear localization of BCL6 is essential for controlling germinal center development and differentiating T helper cells into Th1 and Th2 subsets, which are vital processes in adaptive immune response. Additionally, BCL6 plays a significant role in negatively regulating NFκB expression, thereby inhibiting NFκB-mediated cellular functions important for maintaining cellular homeostasis and preventing excessive inflammatory responses. BCL6 activity is finely tuned through HDAC- and SIR2-dependent acetylation, which downregulates function by preventing recruitment of histone deacetylase complexes, highlighting intricate regulation within cells. Dysregulation of BCL6 is frequently observed in non-Hodgkin′s B cell lymphomas, underscoring importance in oncogenesis and making BCL6 a valuable target for therapeutic intervention. Human BCL6 gene encodes a protein consisting of 706 amino acids, reflecting complexity and essential functions in cellular biology. BCL6 (PG-B6P) antibody is available in a non-conjugated form, providing researchers with a reliable tool to explore multifaceted roles of BCL6 in immune regulation and disease, facilitating advancements in both basic research and clinical applications.

The preferred Bcl-6 antibody is Bcl-6 Antibody (D-8): sc-7388.