BAFF-R Antibody (B-3): sc-365409

BAFF-R Antibody (B-3) is a mouse monoclonal IgG1 antibody that detects BAFF-R in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). BAFF-R, also known as B cell activating factor receptor, plays a pivotal role in the immune system by mediating the survival and maturation of B cells, which are essential for the adaptive immune response. BAFF-R is primarily located on the surface of B cells, where BAFF-R interacts with TALL-1 ligand to promote B cell proliferation and differentiation. BAFF-R′s location in the cell is crucial for initiating signaling pathways that prevent apoptosis in transitional B cells, thereby ensuring their development into fully functional mature B cells. BAFF-R genes are expressed at high levels in the spleen and lymph nodes, which are critical sites for B cell maturation and immune response activation. Anti-BAFF-R antibody (B-3) enables researchers to gain valuable insights into B cell biology and the mechanisms underlying various immune disorders, making BAFF-R antibody (B-3) an essential tool for studies in immunology and related fields.

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BAFF-R Antibody (B-3) References:

1. TNF family member B cell-activating factor (BAFF) receptor-dependent and -independent roles for BAFF in B cell physiology.  |  Sasaki, Y., et al. 2004. J Immunol. 173: 2245-52. PMID: 15294936
2. B cell receptor and BAFF receptor signaling regulation of B cell homeostasis.  |  Khan, WN. 2009. J Immunol. 183: 3561-7. PMID: 19726767
3. The BAFF receptor transduces survival signals by co-opting the B cell receptor signaling pathway.  |  Schweighoffer, E., et al. 2013. Immunity. 38: 475-88. PMID: 23453634
4. BAFF controls neural cell survival through BAFF receptor.  |  Tada, S., et al. 2013. PLoS One. 8: e70924. PMID: 23923031
5. BAFF and BAFF receptor levels correlate with B cell subset activation and redistribution in controlled human malaria infection.  |  Scholzen, A., et al. 2014. J Immunol. 192: 3719-29. PMID: 24646735
6. A BAFF receptor His159Tyr mutation in Sjögren's syndrome-related lymphoproliferation.  |  Papageorgiou, A., et al. 2015. Arthritis Rheumatol. 67: 2732-41. PMID: 26097183
7. High-dose BAFF receptor specific mAb-siRNA conjugate generates Fas-expressing B cells in lymph nodes and high-affinity serum autoantibody in a myasthenia mouse model.  |  Ibtehaj, N. and Huda, R. 2017. Clin Immunol. 176: 122-130. PMID: 28099879
8. Up-regulated BAFF and BAFF receptor expression in patients with intractable temporal lobe epilepsy and a pilocarpine-induced epilepsy rat model.  |  Ma, L., et al. 2017. Seizure. 48: 79-88. PMID: 28441631
9. B-cell activating factor (BAFF), BAFF promoter and BAFF receptor allelic variants in hepatitis C virus related Cryoglobulinemic Vasculitis and Non-Hodgkin's Lymphoma.  |  Gragnani, L., et al. 2022. Hematol Oncol. 40: 658-666. PMID: 35460540
10. Decreased BAFF Receptor Expression and Unaltered B Cell Receptor Signaling in Circulating B Cells from Primary Sjögren's Syndrome Patients at Diagnosis.  |  Neys, SFH., et al. 2022. Int J Mol Sci. 23: PMID: 35563492

The preferred BAFF-R antibody is BAFF-R Antibody (H-1): sc-365410.