BAF53 Antibody (D-3): sc-271226

BAF53 Antibody (D-3) is a mouse monoclonal IgG2a antibody that detects BAF53 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). BAF53, also known as ACTL6A (Actin-Like 6A), is a vital component of the SWI/SNF (SWItch/Sucrose Non-Fermentable) complex, which is essential for chromatin remodeling. This process is crucial for various DNA-related activities, including transcription, replication, and repair, as BAF53 modifies the chromatin structure to facilitate access to DNA. BAF53 plays a significant role in regulating the assembly and activity of the SWI/SNF complex, thereby influencing gene expression through the rearrangement of nucleosomes, the fundamental units of chromatin. BAF53 is involved in several cellular processes, including development, differentiation, and cancer progression, highlighting BAF53′s importance in both normal cellular functions and disease states. BAF53 interacts with various proteins, including BRG1, which is a key ATPase subunit of the SWI/SNF complex, underscoring BAF53′s role in the dynamic regulation of chromatin and gene expression. Anti-BAF53 antibody (D-3) is an invaluable tool for researchers studying the intricate mechanisms of chromatin remodeling and its implications in health and disease.

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BAF53 Antibody (D-3) References:

1. Expression of SMARCF1, a truncated form of SWI1, in neuroblastoma.  |  Takeuchi, T., et al. 2001. Am J Pathol. 158: 663-72. PMID: 11159203
2. TIP49 regulates beta-catenin-mediated neoplastic transformation and T-cell factor target gene induction via effects on chromatin remodeling.  |  Feng, Y., et al. 2003. Cancer Res. 63: 8726-34. PMID: 14695187
3. Silencing the nuclear actin-related protein AtARP4 in Arabidopsis has multiple effects on plant development, including early flowering and delayed floral senescence.  |  Kandasamy, MK., et al. 2005. Plant J. 41: 845-58. PMID: 15743449
4. Skeletrophin, a novel RING molecule controlled by the chromatin remodeling complex, is downregulated in malignant melanoma.  |  Takeuchi, T., et al. 2005. DNA Cell Biol. 24: 339-44. PMID: 15869411
5. Effects of Ser2 and Tyr6 mutants of BAF53 on cell growth and p53-dependent transcription.  |  Lee, JH., et al. 2005. Mol Cells. 19: 289-93. PMID: 15879716
6. BAF53 interacts with p53 and functions in p53-mediated p21-gene transcription.  |  Wang, M., et al. 2007. J Biochem. 142: 613-20. PMID: 17878219
7. Association of BAF53 with mitotic chromosomes.  |  Lee, K., et al. 2007. Mol Cells. 24: 288-93. PMID: 17978584
8. Suppression of HPV E6 and E7 expression by BAF53 depletion in cervical cancer cells.  |  Lee, K., et al. 2011. Biochem Biophys Res Commun. 412: 328-33. PMID: 21821000
9. BAF53a is a potential prognostic biomarker and promotes invasion and epithelial-mesenchymal transition of glioma cells.  |  Meng, L., et al. 2017. Oncol Rep. 38: 3327-3334. PMID: 29039584
10. DNA Damage Triggers the Nuclear Accumulation of RASSF6 Tumor Suppressor Protein via CDK9 and BAF53 To Regulate p53 Target Gene Transcription.  |  Kuleape, JA., et al. 2022. Mol Cell Biol. 42: e0031021. PMID: 34898277

The preferred BAF53 antibody is BAF53 Antibody (E-3): sc-137062.