Ataxin-1 Antibody (B-3): sc-365343

Ataxin-1 Antibody (B-3) is a mouse monoclonal IgG2a antibody that detects Ataxin-1 in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Ataxin-1, also known as spinocerebellar ataxia type 1 protein, plays a crucial role in regulating gene expression and cellular signaling pathways, particularly in neuronal function. Ataxin-1 is vital for maintaining neuronal health, as mutations in Ataxin-1 are linked to spinocerebellar ataxia type 1 (SCA-1), which leads to progressive neuronal loss, muscle wasting, and ataxia. Ataxin-1 is predominantly localized in the cytoplasm and nucleus of Purkinje cells, where Ataxin-1 interacts with other critical proteins such as Purkinje-enriched leucine-rich acidic nuclear protein (LANP) and promyelocytic leukemia protein (PML). In SCA-1, Ataxin-1 undergoes a mutation resulting in a polyglutamine expansion, leading to toxic nuclear aggregates that disrupt normal cellular functions and exacerbate disease pathology. Anti-Ataxin-1 antibody (B-3) serves as an essential tool for researchers studying molecular mechanisms underlying SCA-1 and Ataxin-1′s role in neuronal health.

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Ataxin-1 Antibody (B-3) References:

1. Role of tissue transglutaminase type 2 in calbindin-D28k interaction with ataxin-1.  |  Vig, PJ., et al. 2007. Neurosci Lett. 420: 53-7. PMID: 17442486
2. Ataxin-1 and ataxin-2 intermediate-length PolyQ expansions in amyotrophic lateral sclerosis.  |  Conforti, FL., et al. 2012. Neurology. 79: 2315-20. PMID: 23197749
3. Beyond the glutamine expansion: influence of posttranslational modifications of ataxin-1 in the pathogenesis of spinocerebellar ataxia type 1.  |  Ju, H., et al. 2014. Mol Neurobiol. 50: 866-874. PMID: 24752589
4. Flk-1⁺Sca-1⁻ mesenchymal stem cells: functional characteristics in vitro and regenerative capacity in vivo.  |  Li, Y., et al. 2015. Int J Clin Exp Pathol. 8: 9875-88. PMID: 26617697
5. Ataxin-1 regulates proliferation of hippocampal neural precursors.  |  Asher, M., et al. 2016. Neuroscience. 322: 54-65. PMID: 26876606
6. Ataxin-1 is involved in tumorigenesis of cervical cancer cells via the EGFR-RAS-MAPK signaling pathway.  |  Kang, AR., et al. 2017. Oncotarget. 8: 94606-94618. PMID: 29212253
7. The ataxin-1 interactome reveals direct connection with multiple disrupted nuclear transport pathways.  |  Zhang, S., et al. 2020. Nat Commun. 11: 3343. PMID: 32620905
8. Spinocerebellar Ataxia Type 1 protein Ataxin-1 is signaled to DNA damage by ataxia-telangiectasia mutated kinase.  |  Suart, CE., et al. 2021. Hum Mol Genet. 30: 706-715. PMID: 33772540
9. MicroRNA-136-5p protects cardiomyocytes from coronary microembolization through the inhibition of pyroptosis.  |  Cai, R., et al. 2022. Apoptosis. 27: 206-221. PMID: 35084609
10. Identification of the ataxin-1 interaction network and its impact on spinocerebellar ataxia type 1.  |  Chen, JM., et al. 2022. Hum Genomics. 16: 29. PMID: 35906672

The preferred Ataxin-1 antibody is Ataxin-1 Antibody (E-4): sc-514953.