ASIC4 Antibody (E-8): sc-514818
- ASIC4 Antibody (E-8) is a mouse monoclonal IgG2b κ ASIC4 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 1-24 at the N-terminus of ASIC4 of human origin
- ASIC4 Antibody (E-8) is recommended for detection of ASIC4 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-ASIC4 Antibody (E-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for ASIC4 Antibody (E-8) for WB applications. These reagents are now offered in bundles with ASIC4 Antibody (E-8) (see ordering information below).
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ASIC4 Antibody (E-8) is a mouse monoclonal IgG2b kappa light chain antibody that detects ASIC4 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ASIC4 (E-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ASIC4, also known as ACCN4 and BNAC4, is a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily, which plays a crucial role in sodium ion transport across cell membranes. ASIC4 is predominantly expressed in the pituitary gland and the inner ear, where ASIC4 is involved in sensory transduction and the regulation of fluid balance. ASIC4′s presence in these tissues highlights ASIC4′s importance in physiological processes such as hormone secretion and auditory function. Additionally, ASIC4′s structure, characterized by two hydrophobic transmembrane regions and a cysteine-rich extracellular loop, is essential for proper formation of ion channels that respond to changes in pH and mechanical stimuli. Understanding ASIC4′s role in these contexts can provide insights into potential implications in various physiological and pathological conditions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ASIC4 Antibody (E-8) References:
- The mammalian sodium channel BNC1 is required for normal touch sensation. | Price, MP., et al. 2000. Nature. 407: 1007-11. PMID: 11069180
- Acid-sensing ion channel (ASIC) 4 gene: physical mapping, genomic organisation, and evaluation as a candidate for paroxysmal dystonia. | Gründer, S., et al. 2001. Eur J Hum Genet. 9: 672-6. PMID: 11571555
- A role for ASIC3 in the modulation of high-intensity pain stimuli. | Chen, CC., et al. 2002. Proc Natl Acad Sci U S A. 99: 8992-7. PMID: 12060708
- Overexpression of acid-sensing ion channel 1a in transgenic mice increases acquired fear-related behavior. | Wemmie, JA., et al. 2004. Proc Natl Acad Sci U S A. 101: 3621-6. PMID: 14988500
- Identification of acid-sensing ion channels in bone. | Jahr, H., et al. 2005. Biochem Biophys Res Commun. 337: 349-54. PMID: 16185661
- BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels. | García-Añoveros, J., et al. 1997. Proc Natl Acad Sci U S A. 94: 1459-64. PMID: 9037075
- A proton-gated cation channel involved in acid-sensing. | Waldmann, R., et al. 1997. Nature. 386: 173-7. PMID: 9062189
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ASIC4 Antibody (E-8) | sc-514818 | 200 µg/ml | $322.00 | |||
ASIC4 Antibody (E-8): m-IgGκ BP-HRP Bundle | sc-524852 | 200 µg Ab, 40 µg BP | $361.00 | |||
ASIC4 Antibody (E-8): m-IgG2b BP-HRP Bundle | sc-549190 | 200 µg Ab; 10 µg BP | $361.00 | |||
ASIC4 Antibody (E-8) AC | sc-514818 AC | 500 µg/ml, 25% agarose | $424.00 | |||
ASIC4 Antibody (E-8) HRP | sc-514818 HRP | 200 µg/ml | $322.00 | |||
ASIC4 Antibody (E-8) FITC | sc-514818 FITC | 200 µg/ml | $336.00 | |||
ASIC4 Antibody (E-8) PE | sc-514818 PE | 200 µg/ml | $349.00 | |||
ASIC4 Antibody (E-8) Alexa Fluor® 488 | sc-514818 AF488 | 200 µg/ml | $364.00 | |||
ASIC4 Antibody (E-8) Alexa Fluor® 546 | sc-514818 AF546 | 200 µg/ml | $364.00 | |||
ASIC4 Antibody (E-8) Alexa Fluor® 594 | sc-514818 AF594 | 200 µg/ml | $364.00 | |||
ASIC4 Antibody (E-8) Alexa Fluor® 647 | sc-514818 AF647 | 200 µg/ml | $364.00 | |||
ASIC4 Antibody (E-8) Alexa Fluor® 680 | sc-514818 AF680 | 200 µg/ml | $364.00 | |||
ASIC4 Antibody (E-8) Alexa Fluor® 790 | sc-514818 AF790 | 200 µg/ml | $364.00 | |||
ASIC4 (E-8) Neutralizing Peptide | sc-514818 P | 100 µg/0.5 ml | $69.00 |