AOF1 Antibody (5E10C1): sc-517222
- AOF1 Antibody (5E10C1) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against a recombinant protein corresponding to amino acids 6-129 of AOF1 of human origin
- recommended for detection of AOF1 of human origin by WB, IP, IF, FCM and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for AOF1 Antibody (5E10C1). This work is in progress.
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AOF1 Antibody (5E10C1) is a mouse monoclonal IgG1 antibody that detects AOF1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). AOF1, also known as KDM1B or LSD2, is an 823 amino acid nuclear protein that plays a crucial role in epigenetic regulation by demethylating Lys4 of histone H3, a modification associated with transcriptional activation. This demethylation process is vital for proper gene expression, particularly during oocyte development, where AOF1 is essential for de novo DNA methylation of certain imprinted genes. AOF1 exists in three alternatively spliced isoforms and features a single SWIRM domain, which is important for chromatin regulation function. Additionally, AOF1 contains a CW-type zinc finger and is encoded by a gene located on human chromosome 6p22.3. AOF1′s ability to interact with the N-terminal tail of mono- and dimethylated Lys4 of histone H3 underscores AOF1′s significance in dynamic gene expression regulation, making anti-AOF1 antibody (5E10C1) an invaluable tool for researchers studying epigenetic mechanisms and chromatin dynamics.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AOF1 Antibody (5E10C1) | sc-517222 | 100 µg/ml | $322.00 |