Date published: 2025-9-5

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Amsacrine hydrochloride (CAS 54301-15-4)

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寫評論提問

备用名:
4-(9-Acridinylamino)-N-(methanesulfonyl)-m-anisidine hydrochloride; m-AMSA
应用:
Amsacrine hydrochloride 是 DNA 拓扑异构酶 II 的抑制剂
CAS号码:
54301-15-4
纯度:
≥98%
分子量:
429.92
分子式:
C21H19N3O3S•HCl
补充资料:
此类物品属于危险品,运输时可能需要支付额外运费。
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).

快捷链接

抑制 DNA 拓扑异构酶 II。


Amsacrine hydrochloride (CAS 54301-15-4) 参考文献

Davey, R.A., et al., The potential of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide to circumvent three multidrug-resistance phenotypes in vitro. Cancer Chemother. Pharmacol. 39, 424-430, (1997) Nelson, E.M., et al., Mechanism of antitumor drug action: poisoning of mammalian DNA topoisomerase II on DNA by 4'-(9-acridinylamino)-methanesulfon-m-anisidide. Proc. Natl. Acad. Sci. USA 81, 1361-1365, (1984) Ferguson, L.R., , Application of fluorescence in situ hybridization to study the relationship between cytotoxicity, chromosome aberrations, and changes in chromosome number after treatment with the topoisomerase II inhibitor amsacrine. Environ. Mol. Mutagen. 27, 255, (1996) Mosesso, P., et al., Induction of chromosomal aberrations (unstable and stable) by inhibitors of topoisomerase II, m-AMSA and VP16, using conventional Giemsa staining and chromosome painting techniques. Mutagenesis 13, 39-43, (1998) Del Bino, G., et al., The concentration-dependent diversity of effects of DNA topoisomerase I and II inhibitors on the cell cycle of HL-60 cells. Exp. Cell Res. 195, 485-491, (1991) Negri, C., et al., Induction of apoptotic cell death by DNA topoisomerase II inhibitors. Biochimie 77, 893-899, (1995)

订购信息

产品名称产品编号规格价格数量收藏夹

Amsacrine hydrochloride, 10 mg

sc-214540
10 mg
$232.00