Date published: 2025-9-11

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WDR46 抑制因子

WDR46 inhibitors are a class of chemical compounds specifically designed to target and inhibit the activity of the WDR46 protein, also known as WDR46 (WD repeat-containing protein 46). These inhibitors have garnered significant attention in the field of molecular biology and biochemistry due to the critical role that WDR46 plays in various cellular processes. WDR46 is a member of the WD repeat protein family, characterized by its repeating units of approximately 40-60 amino acids that form a β-propeller structure. This protein is primarily found within the nucleus of eukaryotic cells, where it participates in essential cellular functions, including gene transcription, RNA processing, and DNA repair.

WDR46 inhibitors work by binding selectively to the WDR46 protein, thereby interfering with its normal function. The exact mechanism of inhibition may vary among different inhibitors, but the overarching goal is to disrupt the interactions and processes in which WDR46 is involved. By doing so, these inhibitors have the potential to modulate key cellular pathways, offering valuable insights into the fundamental biology of the cell. Researchers have been particularly interested in elucidating the specific roles of WDR46 in gene expression regulation and DNA repair, as inhibiting its activity can help uncover the underlying molecular mechanisms and pathways associated with these processes. This knowledge can ultimately lead to a deeper understanding of cellular biology and may have implications in various fields, such as cancer research, genetic engineering, and the development of novel biotechnological tools.

関連項目

Items 1 to 10 of 12 total

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产品名称CAS #产品编号数量价格应用排名

Taxol

33069-62-4sc-201439D
sc-201439
sc-201439A
sc-201439E
sc-201439B
sc-201439C
1 mg
5 mg
25 mg
100 mg
250 mg
1 g
$40.00
$73.00
$217.00
$242.00
$724.00
$1196.00
39
(2)

如果 WDR46 在细胞骨架动力学或微管相关过程中发挥作用,紫杉醇可能会通过改变微管动力学来影响其功能。

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$62.00
$155.00
$320.00
233
(4)

如果 WDR46 参与了与 mTOR 相关的细胞过程或生长途径,雷帕霉素可能会调节其活性。

Staurosporine

62996-74-1sc-3510
sc-3510A
sc-3510B
100 µg
1 mg
5 mg
$82.00
$150.00
$388.00
113
(4)

如果 WDR46 在特定激酶的下游或与之结合发挥作用,那么石杉碱碱可能会扰乱其活性。

Cycloheximide

66-81-9sc-3508B
sc-3508
sc-3508A
100 mg
1 g
5 g
$40.00
$82.00
$256.00
127
(5)

对蛋白质合成的普遍抑制作用可降低WDR46或其相互作用伴侣的水平。

Brefeldin A

20350-15-6sc-200861C
sc-200861
sc-200861A
sc-200861B
1 mg
5 mg
25 mg
100 mg
$30.00
$52.00
$122.00
$367.00
25
(3)

如果WDR46在囊泡运输或ER/高尔基体中的蛋白质加工中发挥作用,那么brefeldin A可能会破坏其功能。

Wortmannin

19545-26-7sc-3505
sc-3505A
sc-3505B
1 mg
5 mg
20 mg
$66.00
$219.00
$417.00
97
(3)

如果 WDR46 在 PI3K 信号通路中起作用,那么沃特曼素可能会影响其活性。

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$121.00
$392.00
148
(1)

与去甲斑蝥素类似,如果 WDR46 是 PI3K 相关途径的一部分,其活性也会受到影响。

Nocodazole

31430-18-9sc-3518B
sc-3518
sc-3518C
sc-3518A
5 mg
10 mg
25 mg
50 mg
$58.00
$83.00
$140.00
$242.00
38
(2)

如果 WDR46 参与微管动力学,那么 nocodazole 可能会通过破坏微管来改变其功能。

Actinomycin D

50-76-0sc-200906
sc-200906A
sc-200906B
sc-200906C
sc-200906D
5 mg
25 mg
100 mg
1 g
10 g
$73.00
$238.00
$717.00
$2522.00
$21420.00
53
(3)

通过抑制 RNA 合成,放线菌素 D 可减少 WDR46 或其相关伙伴的表达。

SB 203580

152121-47-6sc-3533
sc-3533A
1 mg
5 mg
$88.00
$342.00
284
(5)

如果 WDR46 在 p38 MAPK 通路中发挥作用,其活性可能会受到 SB203580 的调节。