Date published: 2025-9-11

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FAM180A激活剂

FAM180A activators are chemical agents designed to modulate the function of the protein encoded by the FAM180A gene. The acronym FAM180A stands for 'family with sequence similarity 180 member A', which indicates that this gene is part of a larger family of genes sharing sequence homology. The precise biological role of FAM180A is complex and multifaceted, with the protein it encodes being involved in various cellular processes. The activators targeting this protein are developed to interact specifically with its structure, leading to an increase in its natural activity within the cells. These activators can be small molecules, peptides, or other forms of biochemical agents that bind to the FAM180A protein, altering its conformation, stability, or interactions with other cellular components, ultimately resulting in the modulation of its function.

The development and study of FAM180A activators involve a deep understanding of the protein's structure-function relationship. The protein's three-dimensional conformation, along with the specific domains that are critical for its activity, must be thoroughly analyzed to design effective activators. This is often achieved through techniques such as X-ray crystallography, NMR spectroscopy, or cryo-electron microscopy, which provide insights into the atomic details of the protein. Once potential binding sites are identified, activators are crafted through a process of rational design, high-throughput screening, or a combination of both, to find molecules that can bind with high affinity and specificity. These activators are then subject to various biochemical assays to confirm their mechanism of action and to determine how they influence the protein's activity. The goal of such studies is to elucidate the fundamental biological mechanisms by which FAM180A operates and to explore the intricate web of interactions it has within the cell.

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产品名称CAS #产品编号数量价格应用排名

Ionomycin

56092-82-1sc-3592
sc-3592A
1 mg
5 mg
$76.00
$265.00
80
(4)

离子霉素是一种钙离子载体,可增加细胞内钙浓度。钙浓度升高可激活钙调蛋白依赖性蛋白激酶(CaMK),后者可磷酸化FAM180A并增强其活性。

A23187

52665-69-7sc-3591
sc-3591B
sc-3591A
sc-3591C
1 mg
5 mg
10 mg
25 mg
$54.00
$128.00
$199.00
$311.00
23
(1)

A23187与离子霉素一样,是一种钙离子载体,可以提高细胞内钙离子水平。随后钙依赖性信号传导途径的激活可能会增强FAM180A的活性。

PMA

16561-29-8sc-3576
sc-3576A
sc-3576B
sc-3576C
sc-3576D
1 mg
5 mg
10 mg
25 mg
100 mg
$40.00
$129.00
$210.00
$490.00
$929.00
119
(6)

Phorbol 12-myristate 13-acetate (PMA)激活蛋白激酶C(PKC),从而可能导致参与各种信号传导途径的蛋白质磷酸化,其中可能包括与FAM180A相关的蛋白质。

IBMX

28822-58-4sc-201188
sc-201188B
sc-201188A
200 mg
500 mg
1 g
$159.00
$315.00
$598.00
34
(1)

异丁基甲基黄嘌呤(IBMX)是磷酸二酯酶的非特异性抑制剂,可导致 cAMP 水平升高。这种升高会增强 PKA 的活性,从而间接增强 FAM180A 的功能。

Calyculin A

101932-71-2sc-24000
sc-24000A
sc-24000B
sc-24000C
10 µg
100 µg
500 µg
1 mg
$160.00
$750.00
$1400.00
$3000.00
59
(3)

萼萼甲是蛋白磷酸酶 1 和 2A 的强效抑制剂,可导致蛋白质(可能包括 FAM180A)的磷酸化水平升高,从而增强其活性。

Okadaic Acid

78111-17-8sc-3513
sc-3513A
sc-3513B
25 µg
100 µg
1 mg
$285.00
$520.00
$1300.00
78
(4)

冈田酸是另一种蛋白磷酸酶抑制剂,可导致蛋白质持续磷酸化。它可能会通过增强磷酸化间接提高 FAM180A 的活性。

Dibutyryl-cAMP

16980-89-5sc-201567
sc-201567A
sc-201567B
sc-201567C
20 mg
100 mg
500 mg
10 g
$45.00
$130.00
$480.00
$4450.00
74
(7)

二丁烯酰 cAMP 是一种细胞渗透性 cAMP 类似物,可激活 PKA。PKA 的激活可导致磷酸化事件,从而增强 FAM180A 的活性。

(−)-Epigallocatechin Gallate

989-51-5sc-200802
sc-200802A
sc-200802B
sc-200802C
sc-200802D
sc-200802E
10 mg
50 mg
100 mg
500 mg
1 g
10 g
$42.00
$72.00
$124.00
$238.00
$520.00
$1234.00
11
(1)

表没食子儿茶素没食子酸酯(EGCG)是一种多酚,可抑制多种蛋白激酶,从而可能改变磷酸化模式,间接增强 FAM180A 的活性。

D-erythro-Sphingosine-1-phosphate

26993-30-6sc-201383
sc-201383D
sc-201383A
sc-201383B
sc-201383C
1 mg
2 mg
5 mg
10 mg
25 mg
$162.00
$316.00
$559.00
$889.00
$1693.00
7
(1)

Sphingosine-1-phosphate是一种生物活性脂质,可激活与细胞存活和增殖相关的信号通路,从而激活包括FAM180A在内的信号级联。

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$121.00
$392.00
148
(1)

LY294002是一种PI3K抑制剂,可以改变细胞信号通路的平衡,通过替代途径或补偿机制增加FAM180A的活性。