FAM180A Inhibitors
FAM180A inhibitors interfere with specific cellular signaling pathways to decrease the activity of FAM180A. Erlotinib targets the EGFR pathway, where it prevents the phosphorylation of downstream proteins; if FAM180A's function is connected to this pathway, Erlotinib's action would result in its decreased activity. Similarly, Rapamycin, through its interaction with FKBP12, inhibits mTOR signaling. This inhibition may lead to reduced protein synthesis related to FAM180A's functions, decreasing its activity. LY294002 and Omipalisib, both act on the PI3K/Akt/mTOR pathway, with LY294002 specifically inhibiting PI3K and Omipalisib inhibiting both PI3K and mTOR. If FAM180A is involved in this pathway, these compounds would diminish its activity by lessening the downstream signaling.
Additionally, other compounds target various kinases and signaling molecules that might be upstream activators or regulators of FAM180A. SB203580, U0126, Triciribine, and PD0325901 inhibit different components of the MAPK signaling cascade, potentially leading to decreased FAM180A activity if it is regulated by this pathway. WZ4003 and BIX 02189 inhibit NUAK family kinases and MEK5, respectively, which could lead to reduced activity of FAM180A if it is part of the pathways regulated by these kinases. SP600125's inhibition of JNK signaling might also lead to decreased FAM180A activity if it functions downstream of the JNK pathway. Lastly, Dasatinib, as a Src kinase inhibitor, could decrease FAM180A activity if it is part of Src kinase-regulated signaling events. Each inhibitor works by impeding specific biochemical pathways that, when inhibited, result in the reduced functional activity of FAM180A, illustrating the complex network of cellular signaling that governs protein activity.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Erlotinib, Free Base | 183321-74-6 | sc-396113 sc-396113A sc-396113B sc-396113C sc-396113D | 500 mg 1 g 5 g 10 g 100 g | $85.00 $132.00 $287.00 $495.00 $3752.00 | 42 | |
Erlotinib is an EGFR inhibitor that can prevent the phosphorylation of downstream proteins. If FAM180A is involved in EGFR signaling, its activity could be indirectly decreased by Erlotinib's action in this pathway. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin binds to FKBP12 and inhibits mTOR signaling, which could lead to a reduction in protein synthesis including proteins that function in pathways where FAM180A is active, thereby reducing FAM180A's functional activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that would decrease Akt phosphorylation. If FAM180A operates downstream of PI3K/Akt, this compound would indirectly reduce FAM180A activity by decreasing the signaling through this pathway. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
As a p38 MAPK inhibitor, SB203580 could decrease the activity of transcription factors regulated by p38 MAPK. If FAM180A is regulated by p38 MAPK, its activity could be indirectly reduced. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK, which acts upstream of ERK. If FAM180A is regulated by the MEK/ERK pathway, then U0126 could lead to a decrease in FAM180A activity. | ||||||
Triciribine | 35943-35-2 | sc-200661 sc-200661A | 1 mg 5 mg | $102.00 $138.00 | 14 | |
Triciribine specifically inhibits AKT phosphorylation. If FAM180A activity depends on AKT signaling, inhibition by Triciribine could result in decreased functional activity of FAM180A. | ||||||
WZ4003 | 1214265-58-3 | sc-473979 | 5 mg | $300.00 | ||
WZ4003 selectively inhibits NUAK family kinases which are AMPK-related kinases. If FAM180A is involved in pathways regulated by NUAK kinases, its activity would be decreased by this inhibition. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
SP600125 is an inhibitor of JNK signaling. If FAM180A functions downstream of the JNK pathway, inhibiting JNK would lead to a decrease in FAM180A functional activity. | ||||||
BIX 02189 | 1094614-85-3 | sc-364436 sc-364436A | 5 mg 10 mg | $220.00 $378.00 | 5 | |
BIX 02189 is a selective inhibitor of MEK5, which is part of the ERK5 pathway. If FAM180A is regulated by ERK5, inhibition by BIX 02189 would result in a reduction of FAM180A activity. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
Dasatinib is a Src kinase inhibitor and if FAM180A is part of the signaling pathways involving Src family kinases, its activity could be indirectly decreased by Dasatinib. | ||||||