SLK Antibody (G-9): sc-515493

SLK Antibody (G-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects SLK protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-SLK antibody (G-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SLK protein, also known as STE20-like kinase or STK2, is a crucial member of the serine/threonine kinase subfamily, Ste20, which is involved in critical signaling pathways that relay information from G protein-coupled receptors to cytosolic MAP kinase cascades. SLK protein is characterized by its N-terminal protein kinase domain, a central coiled-coil domain, and a C-terminal ATH domain, and is ubiquitously expressed in the cytoplasm. SLK protein plays a significant role in various cellular processes, including cellular stress response, cell motility, and cytoskeletal dynamics, and is activated through cleavage by caspase-3. SLK protein interacts with several key proteins, including microtubules, which are essential for maintaining cell shape and facilitating intracellular transport. Understanding SLK interactions and functions is vital for elucidating its role in cellular signaling and implications in various diseases, making SLK (G-9) antibody an invaluable tool for researchers studying these pathways.

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LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

SLK Antibody (G-9) References:

1. Association of the Ste20-like kinase (SLK) with the microtubule. Role in Rac1-mediated regulation of actin dynamics during cell adhesion and spreading.  |  Wagner, S., et al. 2002. J Biol Chem. 277: 37685-92. PMID: 12151406
2. Expression of the Ste20-like kinase SLK during embryonic development and in the murine adult central nervous system.  |  Zhang, YH., et al. 2002. Brain Res Dev Brain Res. 139: 205-15. PMID: 12480135
3. Renal expression and activity of the germinal center kinase SK2.  |  Cybulsky, AV., et al. 2004. Am J Physiol Renal Physiol. 286: F16-25. PMID: 12965890
4. Ste20-like kinase SLK displays myofiber type specificity and is involved in C2C12 myoblast differentiation.  |  Storbeck, CJ., et al. 2004. Muscle Nerve. 29: 553-64. PMID: 15052621
5. The Ste20-like kinase SLK is required for cell cycle progression through G2.  |  O'Reilly, PG., et al. 2005. J Biol Chem. 280: 42383-90. PMID: 16236704
6. Induction of apoptosis by the Ste20-like kinase SLK, a germinal center kinase that activates apoptosis signal-regulating kinase and p38.  |  Hao, W., et al. 2006. J Biol Chem. 281: 3075-84. PMID: 16316999
7. v-Src-dependent down-regulation of the Ste20-like kinase SLK by casein kinase II.  |  Chaar, Z., et al. 2006. J Biol Chem. 281: 28193-9. PMID: 16837460
8. The 3'-untranslated region of the Ste20-like kinase SLK regulates SLK expression.  |  Cybulsky, AV., et al. 2007. Am J Physiol Renal Physiol. 292: F845-52. PMID: 17003224
9. Ste20-related kinase SLK phosphorylates Ser188 of RhoA to induce vasodilation in response to angiotensin II Type 2 receptor activation.  |  Guilluy, C., et al. 2008. Circ Res. 102: 1265-74. PMID: 18420945

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SLK Antibody (G-9) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-SLK Antibody (G-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SLK Antibody (G-9) Specifications

Alternate Product Name: SLK

Product Clone Name: G-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1186-1235

Epitope Target: SLK

Epitope Species: human

Product Reactivity/Detection: SLK

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for SLK Antibody (G-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin