SLK Activators
SLK Activators belong to a distinctive chemical class known for their ability to modulate the activity of SLK (STE20-like kinase), a member of the sterile 20 (STE20) family of serine/threonine protein kinases. These compounds are characterized by their unique structural features and targeted interaction with the catalytic domain of SLK. The primary function of SLK, a conserved kinase across various species, involves regulating cellular processes such as cell cycle progression, cytoskeletal dynamics, and cell migration. SLK Activators play a crucial role in influencing these processes by specifically activating the kinase, thereby initiating downstream signaling cascades.
Structurally, SLK Activators often possess a distinct molecular scaffold designed to fit into the active site of SLK. The interaction between the activator and the kinase triggers conformational changes in SLK, leading to its activation and subsequent phosphorylation of specific substrates. This activation, in turn, modulates various cellular pathways associated with SLK, contributing to the finely tuned regulation of cellular functions. Researchers and drug developers are exploring the potential of SLK Activators in elucidating the physiological roles of SLK and its impact on cellular behavior. The unique mechanism of action exhibited by these compounds provides a valuable tool for dissecting the intricate signaling pathways governed by SLK, shedding light on its broader implications in cellular physiology and contributing to the growing body of knowledge in the field of kinase modulation.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a diester of phorbol and is known to activate protein kinase C (PKC), which can then phosphorylate various target proteins, including kinases that are upstream of SLK. The activation of PKC is therefore expected to enhance the phosphorylation and activation of SLK due to downstream signaling effects. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, increasing the levels of cAMP in cells. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate and thereby enhance the activity of SLK by altering its conformation or interaction with upstream activators. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin binds to the insulin receptor, triggering a signaling cascade that includes the PI3K/Akt pathway. Akt can phosphorylate and activate various downstream targets, potentially enhancing the activity of SLK. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Calyculin A is a serine/threonine phosphatase inhibitor, which leads to the accumulation of phosphorylated proteins. By inhibiting dephosphorylation, it can indirectly enhance the phosphorylation status and activity of SLK. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Similar to Calyculin A, Okadaic Acid is also a potent inhibitor of protein phosphatases 1 and 2A, leading to increased phosphorylation and presumptive activation of proteins including SLK. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels. Elevated calcium can activate calmodulin-dependent kinase (CaMK), which may then phosphorylate and enhance the activity of SLK via downstream signaling events. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that also activates stress-activated protein kinases (SAPKs) like JNK. Activation of JNK pathway can lead to the activation of SLK as part of the cellular response to stress. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $45.00 $56.00 $183.00 | 142 | |
Sodium Orthovanadate is an inhibitor of protein tyrosine phosphatases. By preventing dephosphorylation, it can enhance the phosphorylation state and activity of tyrosine-phosphorylated proteins, potentially including SLK. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits GSK-3, a kinase that can regulate a variety of proteins through phosphorylation. Inhibition of GSK-3 can result in altered activities of downstream proteins, which could include the enhancement of SLK activity. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $92.00 $182.00 | 71 | |
H-89 is an inhibitor of protein kinase A (PKA), which can lead to alterations in the phosphorylation states of PKA substrates and potentially enhance the activity of SLK through compensatory cellular mechanisms. | ||||||