IL-27Rα Antibody (J126): sc-80078

IL-27Rα Antibody (J126) is a mouse monoclonal IgG2b antibody that detects IL-27Rα in human samples through applications such as western blotting (WB) and immunoprecipitation (IP). IL-27Rα, also known as WSX-1, is a crucial component of the IL-27 signaling pathway, which plays a significant role in the immune response by mediating the effects of the cytokine IL-27. IL-27Rα is primarily located on the surface of immune cells, including naive CD4-positive T cells, where IL-27Rα facilitates the clonal expansion and differentiation of these cells into a Th1 phenotype, promoting the production of gamma-interferon. IL-27Rα expression on these cells is vital for the adaptive immune response, as IL-27Rα allows for effective communication between cytokines and T cells, ultimately influencing the outcome of immune responses against pathogens. Additionally, IL-27Rα interacts with the gp130 receptor, which is essential for signal transduction, leading to the activation of various transcription factors, including Stat1 and Stat3. IL-27Rα expression and interaction with IL-27 is critical for maintaining immune homeostasis and preventing excessive inflammation, making IL-27Rα an important target for therapeutic interventions in autoimmune diseases and other immune-related disorders.

The preferred IL-27Rα antibody is IL-27Rα Antibody (F-7): sc-376309.