HCF2 Antibody (D-12): sc-393251

HCF2 Antibody (D-12) is a mouse monoclonal IgG2b antibody that detects HCF2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). HCF2, a crucial player in the herpes simplex virus (HSV) lifecycle, is a smaller homolog of HCF1 and is essential for the assembly of the multiprotein complex with VP16 and Oct-1, which activates the viral immediate-early genes. The interaction between HCF2 and VP16 is particularly significant as HCF2 influences the efficiency of complex formation, thereby impacting the transcriptional regulation of HSV. The structural differences between HCF1 and HCF2, particularly in the kelch repeats of their beta-propeller domains, dictate the binding affinity to VP16, which is vital for the precise regulation of the HSV lytic-latent cycle. Understanding the role of HCF2 in this context not only sheds light on viral gene expression but also highlights potential therapeutic targets for HSV infections. Anti-HCF2 antibody (D-12) is an invaluable tool for researchers studying the molecular mechanisms of HSV and its interactions within host cells.

The preferred HCF2 antibody is HCF2 Antibody (C-6): sc-393250.