DDEFL1 Antibody (H-9): sc-365840

DDEFL1 Antibody (H-9) is a mouse monoclonal IgG1 antibody that detects DDEFL1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). DDEFL1, also known as development and differentiation enhancing factor-like 1, ACAP4, UPLC1, CENTB6, or ASAP3, is a 903 amino acid cytoplasmic protein that plays a crucial role in cellular processes by acting as an ADP-ribosylation factor GTPase-activating protein. DDEFL1 contains two ankyrin repeats, an Arf-GAP domain, and a pleckstrin homology (PH) domain, which are essential for catalyzing the hydrolysis of GTP bound to Arf proteins. This activity is vital for regulating intracellular trafficking and signal transduction pathways, thereby influencing cell differentiation and migration. DDEFL1 is predominantly expressed in lung, liver, blood leukocytes, and primary hepatocarcinoma, and dysregulation has been implicated in the pathogenesis of hepatocellular carcinoma. The presence of two isoforms produced by alternative splicing events adds complexity to functional roles, and the gene encoding DDEFL1 is located on human chromosome 1, which spans 260 million base pairs and contains over 3,000 genes, representing nearly 8% of the human genome. anti-DDEFL1 antibody (H-9) is an invaluable tool for researchers studying the molecular mechanisms underlying cell differentiation and cancer progression.

The preferred DDEFL1 antibody is DDEFL1 Antibody (C-3): sc-514132.