Molecular structure of Theophylline, CAS Number: 58-55-9
Theophylline (CAS 58-55-9)
See product citations (6)
Alternate Names:
1,3-Dimethylxanthine; 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione
Application:
Theophylline is an inhibitor of cyclic phosphodiesterase
CAS Number:
58-55-9
Purity:
≥98%
Molecular Weight:
180.16
Molecular Formula:
C7H8N4O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Theophylline is a xanthine alkaloid that serves as an important compound in respiratory research. It is primarily used to study its mechanism of action, which involves inhibition of phosphodiesterase, leading to an increase in intracellular cyclic AMP levels. This action is of interest in the investigation of airway smooth muscle relaxation and the regulation of bronchomotor tone. In addition, theophylline is used to explore its effects on the respiratory drive at the central nervous system level, where it is known to stimulate the medullary respiratory center. Researchers also examine the impact of theophylline on diaphragmatic contractility and its potential to enhance respiratory muscle function. Furthermore, theophylline′s role in influencing anti-inflammatory pathways is studied to understand its broader effects on pulmonary physiology.
Theophylline (CAS 58-55-9) References
- Sodium theophylline glycinate. | KRANTZ, JC. and HOLBERT, JM. 1947. J Am Pharm Assoc Am Pharm Assoc. 36: 248-50. PMID: 20256465
- Clinical pharmacology of theophylline in preterm infants: effects, metabolism and pharmacokinetics. | Pacifici, GM. 2014. Curr Pediatr Rev. 10: 297-303. PMID: 25594527
- Therapeutic monitoring of theophylline. Rationale and current status. | Bierman, CW. and Williams, PV. 1989. Clin Pharmacokinet. 17: 377-84. PMID: 2689038
- Theophylline-isoniazid interaction. | Torrent, J., et al. 1989. DICP. 23: 143-5. PMID: 2728504
- The Impact of CYP1A2 and CYP2E1 Genes Polymorphism on Theophylline Response. | Sutrisna, E. 2016. J Clin Diagn Res. 10: FE01-FE03. PMID: 28050398
- Therapeutic consequences of drug interactions with theophylline pharmacokinetics. | Jonkman, JH. 1986. J Allergy Clin Immunol. 78: 736-42. PMID: 2877015
- Sustained release theophylline preparations. Practical recommendations for prescribing and therapeutic drug monitoring. | Glynn-Barnhart, A., et al. 1988. Drugs. 35: 711-26. PMID: 3048977
- The clinical use and measurement of theophylline. | Rowe, DJ., et al. 1988. Ann Clin Biochem. 25 (Pt 1): 4-26. PMID: 3281555
- Dose-dependent kinetics of theophylline. | Lesko, LJ. 1986. J Allergy Clin Immunol. 78: 723-7. PMID: 3534053
- Neonatal theophylline neurotoxicity. | Clancy, RR., et al. 1985. Clin Pediatr (Phila). 24: 168-70. PMID: 3971645
- Pharmacokinetic drug interactions with theophylline. | Jonkman, JH. and Upton, RA. 1984. Clin Pharmacokinet. 9: 309-34. PMID: 6147220
- Propafenone-theophylline interaction. | Spinler, SA., et al. 1993. Pharmacotherapy. 13: 68-71. PMID: 8437970
- Pharmacokinetics and interactions of digoxin, theophylline and furosemide in diseases with edema. | Macolić, V. and Vrhovac, B. 1993. Int J Clin Pharmacol Ther Toxicol. 31: 6-11. PMID: 8444517
Inhibitor of:
4933425L06Rik, 5′-nucleotidase, Adenosine A Receptor, Adenosine A1-R, ADK, Akp-3, Akp-6, ALDH4A1, Alpi, ART2A, ART3, C2orf89, cAMP, CD73, CRY2, CysLT1 Receptor, ECP, HGD, IAP, IgE, IL-13Rα2, Obox2, Olfr1031, Olfr1065, Olfr107, Olfr74, Olfr792, Olfr794, Olfr798, Olfr823, Olr242, Olr483, pADPr, PDE, PDE4A, PDE6G, PDE6H, PDXDC1, PDXDC2, PKA IIβ reg, RSHL3, Siglec-8, TRPV5, Tryptase, and UGRP1.Activator of:
α-S1-casein, 1810020O05Rik, 2′-PDE, 5′-nucleotidas, 5′-nucleotidase, A1-c, AADACL4, Adad2, Adenosine A2A-R, ADM Receptor, AdSS2, AKAP 149_AKAP 121, AMPD2, AQP12A, Atase, ATPBD4, Basal ciliated, BC031181, Bcy1, BGT-1, BTR1, C19orf45, C1orf94, C4BPα, C9orf30, CA II, CA V, calicin, casein kinase IIβ, CCDC36, CCK-AR, Cdc35, CdcA7, CEP290, CHT1, CINAP, CNBD1, CNBD2, CNG-1, CNG-3, cortistatin, CPB, CREST, CRISP-2, CTGLF6, CYP2E1, cytochrome b5, DNAH1, DNAH14, DOHH, E4BP4, EGL-27, ENT4, eoxtaxin-3, EPI64, EPX, FACL6, FAM18B, FAM194A, FAM55C, FBP1, Fc ε RIβ, Fhit, FOXD1, Gα t2, GABAA Rγ4, GAL4 (DBD), GCG, GCS-β-2, Giantin, gp100, Gpr165, GPR52, Gucy2g, H2-T3, HDHD2, Histone cluster 3 H2A, HMGI-C, HoxA4, HoxB2, HTR3C, IL-7R, INTS7, IQCF2, IVNS1ABP, KRTAP12-3, KRTAP16-10, KRTAP16-5, KRTAP2-2, KRTAP2-4, KRTAP4-12, KRTAP5-6, L-Asparaginase, L-type Ca++ α1S, L-type Ca++ CP γ8, Lce1a1, LMBRD2, LOC100039946, LOC100041224, LOC100041244, LOC100041281, LOC401317, LOC642781, Ly6g, Maskin, Mast Cell Protease 10, MATP, MC4-R, MCF2L2, MFF, MRP-L16, MRP5, MSH, NBC4, Nph1, NT5C1B, NT5C2, NT5DC1, NT5DC2, NUDT19, NUDT6, OBP-2A, OBP-2B, OBSL1, Olfr1018, Olfr1079, Olfr1090, Olfr1095, Olfr1105, Olfr111, Olfr1274, Olfr176, Olfr298, Olfr303, Olfr392, Olfr434, Olfr790, Olfr791, Olfr792, Olfr794, Olfr798, Olfr799, Olfr8, Olfr800, Olfr801, Olfr802, Olfr803, Olfr804, Olfr805, Olfr806, Olfr807, Olfr808, Olfr809, Olfr810, Olfr811, Olfr813, OR10T2, OR11H1, OR1D2, OR1D5, OR1E2, OR1J1, OR1J4, OR1L1, OR1L6, OR1M1, OR1N2, OR2A25, OR2G6, OR2M5, OR2T10, OR2T3, OR2T4, OR2W3, OR3A1, OR4D6, OR4E2, OR4F3, OR4F5, OR4K14, OR4K17, OR4K2, OR4K5, OR4M1, OR5C1, OR5K1, OR5K2, OR6K2, OR6K3, OR6Y1, OR7E24, OR8K1, OTTMUSG00000003947, OTTMUSG00000004010, OTTMUSG00000004012, OTTMUSG00000004013, OTTMUSG00000004461, OTTMUSG00000004551, OTTMUSG00000004963, P2RY8, P2X5, PARP L, PARP-11, PAWP, PCDH11Y, PCDHA3, PCDHGA4, PCM1, PDE10A, PDE11A, PDE1B, PDE2A, PDE4A, PDE4D, PDE6α, PDE6β, PDE6Aα, PDE8A, PDE9A, PHF6, PHKA2, PHKG2, PHM27, PHT2, PKA IIα reg, PKA IIβ reg, PKD2, pki β, Placental lactogen, Pmel17, Popeye 3, Punc, RASL10B, RBM12B, RBM3, RBMY1E, rcRPE, REEP3, Relaxin 2, Relaxin 3, RPAP2, Rpp25, RSP3, RTP1, SEC14L1, Semenogelin-1, Sfta2, SIV Tat, SLC17A9, SP-D, SPAG5, Spastin, SV2A, TAF II p20, TCEAL5, TCP-11, TCTA, TMEM218, TMEM25, Tra-2α, Troponin T-SS, Twinkle, Txl-2, UPase 2, URB2, URO-9, UT-B, Vmn1r-ps4, Vmn1r115, Vmn1r77, VZV Major Capsid Protein, ZCCHC5, ZNF225, ZNF488, and ZNF659.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Theophylline, 5 g | sc-202835 | 5 g | $20.00 | |||
Theophylline, 25 g | sc-202835A | 25 g | $31.00 | |||
Theophylline, 100 g | sc-202835B | 100 g | $83.00 |