N-Methyl-D-Aspartic acid (NMDA) (CAS 6384-92-5)

N-Methyl-D-Aspartic acid (NMDA) is a excitatory amino acid neurotransmitter predominantly present in the central nervous system (CNS). As a vital component of the glutamate-mediated excitatory neurotransmitter system, it plays a key role in facilitating long-term potentiation, an essential process for learning and memory formation. Its influence extends to various physiological processes encompassing neuroplasticity, neuronal development, and neuroprotection. N-Methyl-D-Aspartic acid (NMDA) acts through ligand-gated ion channels known as NMDA receptors, which are activated upon binding with N-Methyl-D-Aspartic acid (NMDA). Activation of these receptors allows the influx of calcium ions into the cell, leading to diverse physiological responses like neuronal excitation, synaptic plasticity, and long-term potentiation. N-Methyl-D-Aspartic acid (NMDA)′s impact spans several biochemical and physiological aspects, encompassing the regulation of neuronal excitability, synaptic plasticity, and long-term potentiation. It has also demonstrated involvement in neuronal development, synaptic plasticity, and long-term potentiation regulation. Furthermore, N-Methyl-D-Aspartic acid (NMDA) has exhibited various physiological effects such as anxiolytic, antidepressant, and anticonvulsant properties. N-Methyl-D-Aspartic acid (NMDA) itself can act as a synthetic agonist of the NMDA receptor, mimicking the binding action of the endogenous ligand glutamate. This receptor, a voltage-gated ion channel, is intricately involved in memory, spatial learning, and perturbing its normal behavior through N-Methyl-D-Aspartic acid (NMDA) exposure has aided in understanding NMDA receptor-mediated activities.