Cl-4AS-1 An inhibitor of 5α-Reductase 1 and 5α-Reductase 2

Cl-4AS-1 (CAS 188589-66-4)

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Application: An inhibitor of 5α-Reductase 1 and 5α-Reductase 2
CAS Number: 188589-66-4
Molecular Weight: 441.01
Molecular Formula: C26H33ClN2O2
* Refer to Certificate of Analysis for lot specific data (including water content).

Cl-4AS-1 is a potent steroidal androgen receptor agonist that has been reported to mimic the action of 5α-dihydrotestosterone (DHT). Additional studies have shown that this compound inhibits 5α-Reductase 1 and 5α-Reductase 2.


References

1. Tolman, R.L., et al. 1997. J. Steroid. Biochem. Mol. Biol. 60 :303-309. PMID: 9219921
2. Schmidt, A., et al. 2009. J. Biol. Chem. 284: 36367-26376. PMID: 19846549

Physical State :
Solid
Solubility :
Soluble in ethanol (10 mM), and DMSO (10 mM).
Storage :
Store at room temperature
Boiling Point :
631.13° C at 760 mmHg (Predicted)
Density :
1.21 g/cm3 (Predicted)
Refractive Index :
n20D 1.59 (Predicted)
IC50 :
Steroidal androgen receptor agonist: IC50 = 12 nM; 5α-reductase type I: IC50 = 6 nM; 5α-reductase type II: IC50 = 10 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
SMILES :
C[C@@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2C(=O)Nc4ccccc4Cl)CCC5[C@@]3(C=CC(=O)N5C)C

Download SDS (MSDS)

Certificate of Analysis

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