Biperiden hydrochloride A muscarinic receptor antagonist

Biperiden hydrochloride (CAS 1235-82-1)

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Synonym: Akineton; Akinophyl
Application: A muscarinic receptor antagonist
CAS Number: 1235-82-1
Purity: ≥97%
Molecular Weight: 347.92
Molecular Formula: C21H29NO•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Biperiden hydrochloride is a muscarinic receptor (mAChR M) antagonist that displays some selectivity for the mAChR M1 subtype (Ki values are 0.48, 2.4, 3.9, 6.3 and 6.3 nM for mAChR M1, mAChR M4, mAChR M3, mAChR M2 and mAChR M5 receptors, respectively).


References

Bolden et al (1992) Antagonism by antimuscarinic and neuroleptic compounds at the five cloned human muscarinic cholinergic receptors expressed in chinese hamster ovary cells. J.Pharmacol.Exp.Ther. 260 576. Sudo et al (1999) Muscarinic receptor occupancy by biperiden in living human brain. Life Sci. 64 PL99. Brocks (1999) Anticholienrgic drugs used in Parkinson's disease: an overlooked class of drugs from a pharmacokinetic perspective. J.Pharm.Pharmaceut.Sci. 2 39.

Physical State :
Solid
Solubility :
Soluble in water (5 mM), DMSO (10 mM), and methanol.
Storage :
Desiccate at 4° C
Melting Point :
>240° C (dec.)
Refractive Index :
n20D ~1.58 (Predicted)
Ki Data :
mAChR M1 : Ki= 0.48 nM; mAChR M4 : Ki= 2.4 nM; mAChR M3 : Ki= 3.9 nM; mAChR M2 : Ki= 6.3 nM; mAChR M5 : Ki= 6.3 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
TN3706000
PubChem CID :
92151
Merck Index :
14: 1233
MDL Number :
MFCD00797516
EC Number :
214-976-2
Beilstein Registry :
8366991
SMILES :
C1CCN(CC1)CCC(C2CC3CC2C=C3)(C4=CC=CC=C4)O.Cl

Download SDS (MSDS)

Certificate of Analysis

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