Molecular structure of 7-Ethoxycoumarin, CAS Number: 31005-02-4
7-Ethoxycoumarin (CAS 31005-02-4)
Application:
7-Ethoxycoumarin is a substrate for CYP2B6
CAS Number:
31005-02-4
Molecular Weight:
190.20
Molecular Formula:
C11H10O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
7-Ethoxycoumarin (7-EC) is a derivative of coumarin that is found in numerous plant species. Laboratory experiments have employed 7-Ethoxycoumarin to investigate the biological effects associated with coumarin derivatives. Although the precise mechanism of action for 7-Ethoxycoumarin remains incompletely understood, it is hypothesized to function through modulating the activity of various enzymes and proteins that play roles in inflammation and cancer regulation. For instance, 7-Ethoxycoumarin has the ability to inhibit cyclooxygenase-2 (COX-2), an enzyme involved in the generation of inflammatory mediators.
7-Ethoxycoumarin (CAS 31005-02-4) References
- Highly sensitive high-performance liquid chromatographic assay for coumarin 7-hydroxylation and 7-ethoxycoumarin O-deethylation by human liver cytochrome P450 enzymes. | Yamazaki, H., et al. 1999. J Chromatogr B Biomed Sci Appl. 721: 13-9. PMID: 10027632
- 7-ethoxycoumarin deethylation activity in perfused isolated rat brain. | Chikaoka, Y. and Tamura, M. 1999. J Biochem. 125: 634-40. PMID: 10050054
- Use of 7-ethoxycoumarin to monitor multiple enzymes in the human CYP1, CYP2, and CYP3 families. | Waxman, DJ. and Chang, TK. 2006. Methods Mol Biol. 320: 153-6. PMID: 16719387
- Hydrogen peroxide-mediated dealkylation of 7-ethoxycoumarin by cytochrome P450 (CYP107AJ1) from Streptomyces peucetius ATCC27952. | Niraula, NP., et al. 2011. Enzyme Microb Technol. 48: 181-6. PMID: 22112829
- Metabolism of 7-ethoxycoumarin, safrole, flavanone and hydroxyflavanone by cytochrome P450 2A6 variants. | Uno, T., et al. 2013. Biopharm Drug Dispos. 34: 87-97. PMID: 23112005
- Metabolism of 7-ethoxycoumarin, flavanone and steroids by cytochrome P450 2C9 variants. | Uno, T., et al. 2017. Biopharm Drug Dispos. 38: 486-493. PMID: 28758225
- In vitro Drug Metabolism Investigation of 7-Ethoxycoumarin in Human, Monkey, Dog and Rat Hepatocytes by High Resolution LC-MS/MS. | Feng, WY., et al. 2018. Drug Metab Lett. 12: 33-53. PMID: 29669508
- Stimulation of mixed-function oxidation of 7-ethoxycoumarin in periportal and pericentral regions of the perfused rat liver by xylitol. | Belinsky, SA., et al. 1983. Eur J Biochem. 137: 1-6. PMID: 6606574
- The metabolism of 7-ethoxycoumarin and 7-hydroxycoumarin by rat and hairless mouse skin strips. | Moloney, SJ., et al. 1982. Biochem Pharmacol. 31: 4005-9. PMID: 6984334
- Metabolism of coumarin and 7-ethoxycoumarin by rat, mouse, guinea pig, cynomolgus monkey and human precision-cut liver slices. | Steensma, A., et al. 1994. Xenobiotica. 24: 893-907. PMID: 7810171
- Comparison of the metabolism of 7-ethoxycoumarin and coumarin in precision-cut rat liver and lung slices. | Price, RJ., et al. 1995. Food Chem Toxicol. 33: 233-7. PMID: 7896234
- Diverse functions of aromatase: O-deethylation of 7-ethoxycoumarin. | Toma, Y., et al. 1996. Endocrinology. 137: 3791-6. PMID: 8756548
- Induction of cytochrome P450 1A1 in rat liver slices by 7-ethoxycoumarin and 4-methyl-7-ethoxycoumarin. | Kuhn, UD., et al. 1998. Exp Toxicol Pathol. 50: 491-6. PMID: 9784028
Inhibitor of:
CYP2A13.Substrate of:
CYP2B6, and Fluorogenic.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
7-Ethoxycoumarin, 25 mg | sc-207170 | 25 mg | $41.00 | |||
7-Ethoxycoumarin, 100 mg | sc-207170A | 100 mg | $71.00 |