14-3-3 η Antibody (6A12): sc-293464

14-3-3 η Antibody (6A12) is a mouse monoclonal IgG2a kappa light chain antibody that detects 14-3-3 eta protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-14-3-3 eta antibody (6A12) is available as a non-conjugated format. 14-3-3 eta protein plays a crucial role in cellular signaling pathways, particularly in regulating apoptosis, mitogenic signaling, and cell-cycle checkpoints, making 14-3-3 eta protein significant in cancer biology. 14-3-3 eta protein is primarily located in the cytoplasm and nucleus, where 14-3-3 eta protein interacts with various target proteins to modulate their activity. 14-3-3 eta protein′s ability to sequester proteins in the cytoplasm or facilitate their nuclear import/export is vital for maintaining cellular homeostasis and responding to stress signals. 14-3-3 eta protein′s interaction with ligands, which often contain a specific 14-3-3 consensus binding motif, is essential for regulating numerous cellular processes. Disruption of these interactions can lead to aberrant signaling pathways and contribute to various diseases, including cancer. 14-3-3 eta protein′s versatility in binding and regulating multiple proteins underscores 14-3-3 eta protein′s importance as a key player in cellular function and pathology.

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14-3-3 η Antibody (6A12) References:

1. The 4.1/ezrin/radixin/moesin domain of the DAL-1/Protein 4.1B tumour suppressor interacts with 14-3-3 proteins.  |  Yu, T., et al. 2002. Biochem J. 365: 783-9. PMID: 11996670
2. MADM, a novel adaptor protein that mediates phosphorylation of the 14-3-3 binding site of myeloid leukemia factor 1.  |  Lim, R., et al. 2002. J Biol Chem. 277: 40997-1008. PMID: 12176995
3. The 14-3-3 cancer connection.  |  Hermeking, H. 2003. Nat Rev Cancer. 3: 931-43. PMID: 14737123
4. Isoform-specific subcellular localization among 14-3-3 proteins in Arabidopsis seems to be driven by client interactions.  |  Paul, AL., et al. 2005. Mol Biol Cell. 16: 1735-43. PMID: 15659648
5. Downregulation of 14-3-3 Proteins in Alzheimer's Disease.  |  Gu, Q., et al. 2020. Mol Neurobiol. 57: 32-40. PMID: 31487003
6. Diagnostic accuracy of 14-3-3 η protein in rheumatoid arthritis: A meta-analysis.  |  Wang, D., et al. 2020. Int J Rheum Dis. 23: 1443-1451. PMID: 32909672
7. The Role of 14-3-3 η as a Biomarker in Rheumatoid Arthritis.  |  Abdelhafiz, D., et al. 2021. Rheumatol Immunol Res. 2: 87-90. PMID: 36465971
8. 14-3-3 η ETA protein as a potential marker of joint damage in gout.  |  Doğan, İ., et al. 2023. Clin Biochem. 118: 110611. PMID: 37429510
9. 14-3-3: modulators of signaling proteins?  |  Morrison, D. 1994. Science. 266: 56-7. PMID: 7939645
10. Structural organization and chromosomal assignment of the human 14-3-3 eta chain gene (YWHAH).  |  Muratake, T., et al. 1996. Genomics. 36: 63-9. PMID: 8812417
11. The structural basis for 14-3-3:phosphopeptide binding specificity.  |  Yaffe, MB., et al. 1997. Cell. 91: 961-71. PMID: 9428519
12. A novel sphingosine-dependent protein kinase (SDK1) specifically phosphorylates certain isoforms of 14-3-3 protein.  |  Megidish, T., et al. 1998. J Biol Chem. 273: 21834-45. PMID: 9705322

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-14-3-3 η Antibody (6A12) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-14-3-3 η Antibody (6A12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

14-3-3 η Antibody (6A12) Specifications

Alternate Product Name: 14-3-3 eta

Product Clone Name: 6A12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 71-170

Epitope Target: 14-3-3 η

Epitope Species: human

Product Reactivity/Detection: 14-3-3 η

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for 14-3-3 η Antibody (6A12): N/A