Date published: 2026-3-27

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1,4-Dioxane (CAS 123-91-1)

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Alternate Names:
Diethylene ether
Application:
1,4-Dioxane is a compound also known as Diethylene oxide
CAS Number:
123-91-1
Purity:
≥99%
Molecular Weight:
88.11
Molecular Formula:
C4H8O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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1,4-Dioxane is a synthetic industrial chemical known for its clear, colorless appearance and ether-like odor. Structurally, it is characterized as a cyclic ether with a six-membered ring consisting of four carbon atoms and two oxygen atoms at the 1 and 4 positions, which contributes to its excellent solvent properties. This heterocyclic compound is highly miscible with water as well as a wide range of organic solvents, making it particularly useful in various applications within chemical research and manufacturing. In the realm of organic synthesis, 1,4-dioxane is frequently employed as a stable solvent for reaction processes, particularly those involving sensitive reagents, due to its ability to dissolve numerous organic compounds and its relatively inert behavior under reaction conditions. Its applications extend to the study of polymer systems where it is used to dissolve polymers such as polyethylene and polypropylene, facilitating the analysis of their properties and behaviors. Additionally, 1,4-dioxane is utilized in environmental chemistry research to investigate its degradation pathways and mechanisms, given its classification as a probable human carcinogen and its presence as a contaminant in groundwater and industrial effluents. Researchers are particularly interested in its photolytic and microbial degradation processes to better understand and mitigate its environmental impact.


1,4-Dioxane (CAS 123-91-1) References

  1. Effect of dioxane on the conformation of lysozyme at low pH. I. Studies by circular dichroism and viscosity measurements.  |  Izumi, T. and Inoue, H. 1977. J Biochem. 81: 1769-79. PMID: 19446
  2. Tolerance of β-diketone hydrolases as representatives of the crotonase superfamily towards organic solvents.  |  Siirola, E., et al. 2011. Biotechnol Bioeng. 108: 2815-22. PMID: 21809324
  3. Advances in bioremediation of 1,4-dioxane-contaminated waters.  |  Zhang, S., et al. 2017. J Environ Manage. 204: 765-774. PMID: 28625566
  4. 1,4-Dioxane degradation characteristics of Rhodococcus aetherivorans JCM 14343.  |  Inoue, D., et al. 2018. Biodegradation. 29: 301-310. PMID: 29696449
  5. Degradation of 1,4-Dioxane by Xanthobacter sp. YN2.  |  Ma, F., et al. 2021. Curr Microbiol. 78: 992-1005. PMID: 33547937
  6. Removal of 1,4-dioxane during on-site wastewater treatment using nitrogen removing biofilters.  |  Lee, CS., et al. 2021. Sci Total Environ. 771: 144806. PMID: 33548721
  7. Cometabolic degradation of 1,4-dioxane by a tetrahydrofuran-growing Arthrobacter sp. WN18.  |  Wang, P., et al. 2021. Ecotoxicol Environ Saf. 217: 112206. PMID: 33866286
  8. Remedial strategies for abating 1,4-dioxane pollution-special emphasis on diverse biotechnological interventions.  |  Kikani, M., et al. 2022. Environ Res. 214: 113939. PMID: 35921903
  9. Characterization of 1,4-dioxane degrading microbial community enriched from uncontaminated soil.  |  Tang, Y., et al. 2023. Appl Microbiol Biotechnol. 107: 955-969. PMID: 36625913
  10. An integrated assessment of the 1,4-dioxane cancer mode of action and threshold response in rodents.  |  Lafranconi, M., et al. 2023. Regul Toxicol Pharmacol. 142: 105428. PMID: 37277058

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1,4-Dioxane, 500 ml

sc-208794
500 ml
$88.00

1,4-Dioxane, 1 L

sc-208794A
1 L
$154.00

1,4-Dioxane, 4 L

sc-208794B
4 L
$413.00