SMN Antibody (MANSMA1): sc-81555
- SMN Antibody (MANSMA1) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against full length recombinant SMN of human origin, with epitope mapping to amino acids 28-91
- recommended for detection of SMN of mouse, rat and human origin by WB, IP and IF
- See SMN (2B1): sc-32313 for SMN antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for SMN Antibody (MANSMA1) for WB applications. These reagents are now offered in bundles with SMN Antibody (MANSMA1) (see ordering information below).
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SEE ALSO...
SMN Antibody (MANSMA1) is a mouse monoclonal IgG1 antibody that detects SMN in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). SMN, or survival of motor neuron, is a crucial protein involved in the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs), which are essential for pre-mRNA splicing. This process ensures that introns are removed and exons are joined together to form mature mRNA. SMN protein is predominantly located in both the cytoplasm and nucleus, where SMN forms a complex with several other proteins, including Gemin2, Gemin3, and various spliceosomal snRNP proteins. SMN presence in subnuclear bodies known as gems highlights SMN′s role in recycling splicing factors, which maintains efficient gene expression. Mutations in the SMN gene lead to spinal muscular atrophy, a severe neurodegenerative disease characterized by motor neuron loss, underscoring SMN′s importance in neuronal health and function. With SMN′s ability to facilitate snRNP assembly and widespread expression in tissues such as brain, spinal cord, and skeletal muscle, SMN serves as a key player in cellular machinery governing gene regulation and expression.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
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SMN Antibody (MANSMA1) References:
- The SMN complex, an assemblyosome of ribonucleoproteins. | Paushkin, S., et al. 2002. Curr Opin Cell Biol. 14: 305-12. PMID: 12067652
- SMN control of RNP assembly: from post-transcriptional gene regulation to motor neuron disease. | Li, DK., et al. 2014. Semin Cell Dev Biol. 32: 22-9. PMID: 24769255
- Therapeutic strategies for spinal muscular atrophy: SMN and beyond. | Bowerman, M., et al. 2017. Dis Model Mech. 10: 943-954. PMID: 28768735
- Augmenting the SMN Protein to Treat Infantile Spinal Muscular Atrophy. | Kim, JK. and Monani, UR. 2018. Neuron. 97: 1001-1003. PMID: 29518354
- Age-dependent SMN expression in disease-relevant tissue and implications for SMA treatment. | Ramos, DM., et al. 2019. J Clin Invest. 129: 4817-4831. PMID: 31589162
- SMN loss dysregulates microtubule-associated proteins in spinal muscular atrophy model. | Zobaroğlu Özer, P., et al. 2022. Mol Cell Neurosci. 120: 103725. PMID: 35395354
- Bap1/SMN axis in Dpp4+ skeletal muscle mesenchymal cells regulates the neuromuscular system. | Kim, JH., et al. 2022. JCI Insight. 7: PMID: 35603786
- A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II. | Liu, Y., et al. 2022. Nat Commun. 13: 5453. PMID: 36114190
- The TUDOR domain of SMN is an H3K79me1 histone mark reader. | Binda, O., et al. 2023. Life Sci Alliance. 6: PMID: 36882285
- Hepatocyte-intrinsic SMN deficiency drives metabolic dysfunction and liver steatosis in spinal muscular atrophy. | Leow, DM., et al. 2024. J Clin Invest. 134: PMID: 38722695
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SMN Antibody (MANSMA1) | sc-81555 | 200 µg/ml | $322.00 | |||
SMN Antibody (MANSMA1): m-IgG Fc BP-HRP Bundle | sc-539626 | 200 µg Ab; 10 µg BP | $361.00 | |||
SMN Antibody (MANSMA1): m-IgG1 BP-HRP Bundle | sc-541610 | 200 µg Ab; 20 µg BP | $361.00 |