SMN Antibody (H-7): sc-137200
- SMN Antibody (H-7) is a mouse monoclonal IgM κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 1-195 mapping near the N-terminus of SMN of human origin
- recommended for detection of SMN of human origin by WB, IP, IF and ELISA
- See SMN (2B1): sc-32313 for SMN antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgGκ BP-HRP is the preferred secondary detection reagent for SMN Antibody (H-7) for WB applications. This reagent is now offered in a bundle with SMN Antibody (H-7) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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SMN Antibody (H-7) is a mouse monoclonal IgM antibody that detects SMN in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SMN, or survival of motor neuron, is a crucial protein involved in the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs), which are essential for pre-mRNA splicing in the nucleus. The proper functioning of SMN is vital for maintaining motor neuron health, as SMN deficiency leads to spinal muscular atrophy, a severe neurodegenerative disorder characterized by motor neuron loss. SMN exists in multiple isoforms due to alternative splicing and forms a complex with several proteins, including Gemin2, Gemin3, and various spliceosomal snRNP proteins, facilitating snRNP assembly in the cytoplasm and recycling in the nucleus. SMN localization in both cytoplasm and nucleus underscores a dual role in snRNP assembly and pre-mRNA splicing, processes critical for gene expression regulation. SMN presence in various tissues, including brain, spinal cord, and skeletal muscle, highlights importance in overall cellular function and potential impact of dysfunction in various diseases. Anti-SMN antibody (H-7) serves as an invaluable tool for researchers studying molecular mechanisms underlying spinal muscular atrophy and related disorders.
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SMN Antibody (H-7) References:
- The SMN complex: an assembly machine for RNPs. | Battle, DJ., et al. 2006. Cold Spring Harb Symp Quant Biol. 71: 313-20. PMID: 17381311
- Molecular functions of the SMN complex. | Kolb, SJ., et al. 2007. J Child Neurol. 22: 990-4. PMID: 17761654
- SMN in spinal muscular atrophy and snRNP biogenesis. | Coady, TH. and Lorson, CL. 2011. Wiley Interdiscip Rev RNA. 2: 546-64. PMID: 21957043
- Spinal muscular atrophy: the role of SMN in axonal mRNA regulation. | Fallini, C., et al. 2012. Brain Res. 1462: 81-92. PMID: 22330725
- SMN-inducing compounds for the treatment of spinal muscular atrophy. | Lorson, MA. and Lorson, CL. 2012. Future Med Chem. 4: 2067-84. PMID: 23157239
- SMN regulates axonal local translation via miR-183/mTOR pathway. | Kye, MJ., et al. 2014. Hum Mol Genet. 23: 6318-31. PMID: 25055867
- Developmental regulation of SMN expression: pathophysiological implications and perspectives for therapy development in spinal muscular atrophy. | Jablonka, S. and Sendtner, M. 2017. Gene Ther. 24: 506-513. PMID: 28556834
- The role of survival motor neuron protein (SMN) in protein homeostasis. | Chaytow, H., et al. 2018. Cell Mol Life Sci. 75: 3877-3894. PMID: 29872871
- A combinatorial approach increases SMN level in SMA model mice. | Dumas, SA., et al. 2022. Hum Mol Genet. 31: 2989-3000. PMID: 35419606
- Fatal thrombotic microangiopathy case following adeno-associated viral SMN gene therapy. | Guillou, J., et al. 2022. Blood Adv. 6: 4266-4270. PMID: 35584395
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SMN Antibody (H-7) | sc-137200 | 200 µg/ml | $322.00 | |||
SMN Antibody (H-7): m-IgGκ BP-HRP Bundle | sc-550739 | 200 µg Ab; 40 µg BP | $361.00 |