Rho GDI alpha Antibody (4A6): sc-130341

Rho GDIα Antibody (4A6) is a mouse monoclonal IgG1 antibody that detects Rho GDIα in mouse, rat, and human samples through applications such as western blotting (WB) and enzyme-linked immunosorbent assay (ELISA). Rho GDIα, also known as ARHGDIA or GDIA1, is a crucial 204 amino acid protein belonging to the Rho GDI family, primarily localized in the cytoplasm. Rho GDIα functions to inhibit the dissociation of guanosine diphosphate (GDP) from Rho proteins, which prevents the binding of guanosine triphosphate (GTP) and subsequent activation of these signaling molecules. This regulatory mechanism maintains proper cell signaling pathways that govern processes such as cell proliferation and cytoskeletal organization. Additionally, Rho GDIα can undergo post-translational modification through phosphorylation at Ser 101 by p21-activated kinase (αPAK), which inhibits Rho GDIα activity and may lead to positive feedback regulation of certain Rho GDIα target proteins. Rho GDIα′s ability to modulate Rho protein activity underscores Rho GDIα′s importance in cellular functions and highlights anti-Rho GDIα antibody (4A6)′s relevance in research focused on cell signaling and related disorders.

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Rho GDI alpha Antibody (4A6) References:

1. Proteomic profiling drug-induced apoptosis in non-small cell lung carcinoma: identification of RS/DJ-1 and RhoGDIalpha.  |  MacKeigan, JP., et al. 2003. Cancer Res. 63: 6928-34. PMID: 14583493
2. Serine 34 phosphorylation of rho guanine dissociation inhibitor (RhoGDIalpha) links signaling from conventional protein kinase C to RhoGTPase in cell adhesion.  |  Dovas, A., et al. 2010. J Biol Chem. 285: 23296-308. PMID: 20472934
3. Semaphorin 5A and plexin-B3 inhibit human glioma cell motility through RhoGDIalpha-mediated inactivation of Rac1 GTPase.  |  Li, X. and Lee, AY. 2010. J Biol Chem. 285: 32436-45. PMID: 20696765
4. RhoGDIα-dependent balance between RhoA and RhoC is a key regulator of cancer cell tumorigenesis.  |  Giang Ho, TT., et al. 2011. Mol Biol Cell. 22: 3263-75. PMID: 21757538
5. Cellular function of RhoGDI-α mediates the cycling of Rac1 and the regulation of pancreatic beta cell death.  |  Cho, Y., et al. 2012. Transplant Proc. 44: 1083-5. PMID: 22564631
6. TROY interacts with Rho guanine nucleotide dissociation inhibitor α (RhoGDIα) to mediate Nogo-induced inhibition of neurite outgrowth.  |  Lu, Y., et al. 2013. J Biol Chem. 288: 34276-34286. PMID: 24129566
7. SUMOylation of RhoGDIα is required for its repression of cyclin D1 expression and anchorage-independent growth of cancer cells.  |  Cao, Z., et al. 2014. Mol Oncol. 8: 285-96. PMID: 24342356
8. eIF5A1/RhoGDIα pathway: a novel therapeutic target for treatment of spinal cord injury identified by a proteomics approach.  |  Liu, W., et al. 2015. Sci Rep. 5: 16911. PMID: 26593060
9. NF-κB p65 Overexpression Promotes Bladder Cancer Cell Migration via FBW7-Mediated Degradation of RhoGDIα Protein.  |  Zhu, J., et al. 2017. Neoplasia. 19: 672-683. PMID: 28772241
10. Corrigendum to 'NF-κB p65 Overexpression Promotes Bladder Cancer Cell Migration via FBW7-Mediated Degradation of RhoGDIα Protein' [Neoplasia 19 (2017) 672-683].  |  Zhu, J., et al. 2021. Neoplasia. 23: 1179-1182. PMID: 34731786

The preferred Ly-GDI/RhoGDI2/ARHGDIB antibody is Ly-GDI/RhoGDI2/ARHGDIB Antibody (G-12): sc-376473.