PTTG Antibody (G-9): sc-376454

PTTG Antibody (G-9) is a mouse monoclonal IgG1 antibody that detects pituitary tumor transforming gene (PTTG) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PTTG plays a crucial role in cell cycle regulation by acting as an anaphase inhibitor, specifically regulating the separin Esp1, which is essential for chromatid separation during mitosis. This function helps ensure proper chromosome segregation, thereby preventing chromosomal instability, a hallmark of many cancers. PTTG is predominantly expressed in the cytoplasm, with partial localization in the nucleus, and is notably overexpressed in Jurkat cells, as well as detected in human thymus, testis, and placenta. The unique structural features of PTTG, including its basic amino-terminal and acidic carboxy-terminal domains, contribute to its function as a transactivation domain when fused to other DNA binding domains, highlighting its importance in gene regulation and potential implications in oncogenesis. Anti-PTTG antibody (G-9) is an essential tool for researchers studying the mechanisms of cell cycle control and the role of PTTG in cancer biology.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

PTTG Antibody (G-9) References:

1. Expression of PTTG and prc1 genes during telencephalic neurogenesis.  |  Tarabykin, V., et al. 2000. Mech Dev. 92: 301-4. PMID: 10727870
2. Expression of pituitary tumor transforming gene (PTTG) and its binding protein in human astrocytes and astrocytoma cells: function and regulation of PTTG in U87 astrocytoma cells.  |  Tfelt-Hansen, J., et al. 2004. Endocrinology. 145: 4222-31. PMID: 15178645
3. Pituitary tumour transforming gene (PTTG) expression correlates with the proliferative activity and recurrence status of pituitary adenomas: a clinical and immunohistochemical study.  |  Filippella, M., et al. 2006. Clin Endocrinol (Oxf). 65: 536-43. PMID: 16984249
4. PTTG-binding factor (PBF) is a novel regulator of the thyroid hormone transporter MCT8.  |  Smith, VE., et al. 2012. Endocrinology. 153: 3526-36. PMID: 22535767
5. Overexpression of pituitary tumor transforming gene (PTTG) is associated with tumor progression and poor prognosis in patients with esophageal squamous cell carcinoma.  |  Zhang, J., et al. 2014. Acta Histochem. 116: 435-9. PMID: 24176776
6. Identification of peptide-mediated interactions between human PTTG and SH3 domains in pALL gene expression profile.  |  Yan, T., et al. 2017. J Mol Graph Model. 76: 11-16. PMID: 28667917
7. PTTG-1 (Securin) immunoexpression in meningiomas correlates with tumor grade and proliferation rate: potential use as a diagnostic marker of malignancy.  |  Iliadis, A., et al. 2018. APMIS. 126: 295-302. PMID: 29575197
8. Retracted: Bioinformatic Analysis of PTTG Family and Prognosis and Immune Cell Infiltration in Gastric Cancer.  |  International, SC. 2024. Stem Cells Int. 2024: 9896574. PMID: 38298228
9. Exploring the molecular landscape of osteosarcoma through PTTG family genes using a detailed multi-level methodology.  |  Lu, Y., et al. 2024. Front Genet. 15: 1431668. PMID: 39139816
10. Structure, expression, and function of human pituitary tumor-transforming gene (PTTG).  |  Zhang, X., et al. 1999. Mol Endocrinol. 13: 156-66. PMID: 9892021

The preferred PTTG antibody is PTTG Antibody (DCS-280): sc-56207.